Fei Cheng-Ming, Chang Chun-Kang
Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.
Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Feb;27(1):288-291. doi: 10.7534/j.issn.1009-2137.2019.01.047.
Bone marrow (BM) microenvironment appears to play an important role in the pathogenesis of hematological malignancies. Apart from soluble factors and direct cell-cell contact, the extracellular vesicles (EVs) were identified as a third mediator for cell communication within BM microenvironment. Recently, more and more evidences have demonstrated that EVs are also involved in the dysregulation of the BM microenvironment in patients with hematological malignancies. Therefore this review focuses on the biological characteristics of EVs, the clinical value of EVs as biomarkers, the BM microenvironment reprogramming in hematological malignancies by EVs, and the potential role of EVs in drug resistance and therapy of hematological malignancies.
骨髓（BM）微环境似乎在血液系统恶性肿瘤的发病机制中发挥重要作用。除了可溶性因子和直接的细胞间接触外，细胞外囊泡（EVs）被确定为骨髓微环境内细胞通讯的第三种介质。最近，越来越多的证据表明，EVs也参与了血液系统恶性肿瘤患者骨髓微环境的失调。因此，本综述聚焦于EVs的生物学特性、EVs作为生物标志物的临床价值、EVs在血液系统恶性肿瘤中对骨髓微环境的重编程作用，以及EVs在血液系统恶性肿瘤耐药性和治疗中的潜在作用。
