特发性不育症男性的血清双酚 A 浓度。
Serum Bisphenol A concentrations in men with idiopathic infertility.
机构信息
Research in Female Reproduction Postgraduate Course, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece.
出版信息
Food Chem Toxicol. 2019 Mar;125:562-565. doi: 10.1016/j.fct.2019.02.016. Epub 2019 Feb 7.
BACKGROUND
Bisphenol A (BPA) has been associated with male reproductive dysfunction. However, few studies have assessed BPA according to the cause of male infertility.
AIM
To investigate serum BPA concentrations in infertile men according to infertility cause.
PATIENTS AND METHODS
Men with infertility (n = 55) [non-obstructive azoospermia (n = 23), cryptorchidism (n = 12), varicocele (n = 20)] compared with fertile men (n = 25). Serum BPA concentrations were measured along with clinical and hormonal assessment.
RESULTS
BPA was detected in all men, with no difference between infertile and control groups [median (IQR) 0.19 (0.45) vs. 0.18 (0.28) ng/ml, p = 0.689] or among the infertility cause [azoospermia 0.30 (0.69), cryptorchidism 0.12 (0.39), varicocele 0.17 (0.23) ng/ml, p = 0.316]. High concentrations of BPA (>3 ng/ml) were observed only in infertile men. Α negative correlation was observed between ΒΡΑ concentrations and AMH (r = -0.320, p < 0.01).
CONCLUSIONS
Although male infertility cannot be attributed to exposure to BPA, high concentrations of BPA could contribute to infertility.
背景
双酚 A（BPA）与男性生殖功能障碍有关。然而，很少有研究根据男性不育的原因评估 BPA。
目的
根据不育原因调查不育男性血清 BPA 浓度。
患者与方法
与生育力正常男性（n=25）相比，患有不育症的男性（n=55）[非梗阻性无精子症（n=23）、隐睾（n=12）、精索静脉曲张（n=20）]。同时进行临床和激素评估，并测量血清 BPA 浓度。
结果
所有男性均检测到 BPA，不育组与对照组之间无差异[中位数（IQR）0.19（0.45）比 0.18（0.28）ng/ml，p=0.689]或不育原因之间无差异[无精子症 0.30（0.69）、隐睾 0.12（0.39）、精索静脉曲张 0.17（0.23）ng/ml，p=0.316]。高浓度 BPA（>3ng/ml）仅见于不育男性。ΒΡΑ 浓度与 AMH 呈负相关（r=-0.320，p<0.01）。
结论
尽管男性不育不能归因于 BPA 暴露，但 BPA 浓度高可能导致不育。
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