3D打印β-磷酸三钙骨组织工程支架：化学性质对兔胫骨模型生物学特性的影响
3D printed β-TCP bone tissue engineering scaffolds: Effects of chemistry on biological properties in a rabbit tibia model.
作者信息
Nandi Samit Kumar, Fielding Gary, Banerjee Dishary, Bandyopadhyay Amit, Bose Susmita
机构信息
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, India.
W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA.
出版信息
J Mater Res. 2018;33(14):1939-1947. doi: 10.1557/jmr.2018.233. Epub 2018 Jul 27.
In this study the effects of 3D printed SiO and ZnO doped tricalcium phosphate (TCP) scaffolds with interconnected pores were evaluated on the bone formation and healing properties of a rabbit tibial defect model. Pure and doped TCP scaffolds were fabricated by a ceramic powder-based 3D printing technique and implanted into critical sized rabbit tibial defects for up to 4 months. bone regeneration was evaluated using chronological radiological examination, histological evaluations, SEM micrographs and fluorochrome labeling studies. Radiograph results showed that Si/Zn doped samples had slower degradation kinetics than the pure TCP samples. 3D printing of TCP scaffolds improved bone formation. The addition of dopants in the TCP scaffolds improved osteogenic capabilities when compared to the pure scaffolds. In summary, our findings indicate that addition of dopants to the TCP scaffolds enhanced bone formation and in turn leading to accelerated healing.
在本研究中，评估了具有相互连通孔隙的3D打印二氧化硅（SiO）和氧化锌（ZnO）掺杂的磷酸三钙（TCP）支架对兔胫骨缺损模型骨形成和愈合特性的影响。通过基于陶瓷粉末的3D打印技术制备了纯TCP支架和掺杂TCP支架，并将其植入到临界尺寸的兔胫骨缺损中长达4个月。使用按时间顺序的放射学检查、组织学评估、扫描电子显微镜（SEM）显微照片和荧光染料标记研究来评估骨再生情况。X射线照片结果显示，硅/锌掺杂样品的降解动力学比纯TCP样品慢。TCP支架的3D打印改善了骨形成。与纯支架相比，在TCP支架中添加掺杂剂提高了成骨能力。总之，我们的研究结果表明，向TCP支架中添加掺杂剂可增强骨形成，进而加速愈合。
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