Alzaree Fatma A, AbuShady Mones M, Atti Mohamed Abdel, Fathy Gihan A, Galal Essam M, Ali Alaa, Elias Tahany R
Department of Child Health, National Research Centre, Cairo, Egypt.
Department of Medical Biochemistry, Medical Research Division, National Research Centre, Cairo, Egypt.
Open Access Maced J Med Sci. 2019 Jan 12;7(1):77-81. doi: 10.3889/oamjms.2019.035. eCollection 2019 Jan 15.
Insulin-like growth factor 1 (IGF-1) is one of the essential intrauterine hormonal mediators of growth, and its serum values are often low after preterm delivery.
To evaluate the influence of immediate breast milk feeding on serum IGF-1 in preterm newborns.
This prospective, observational cohort study included 60 premature infants born < 32 weeks of gestation, divided into group A and B regarding breastfeeding or formula feeding. Growth measurements were taken at birth. The standard deviation of each measurement was calculated. Serum IGF-I was measured one day postnatal and at a time equivalent to 40 weeks of gestation.
Significant higher level of mean serum IGF-1 was detected in group A than B at postnatal age equivalent to 40 weeks of gestation. In group A, the higher significant level was detected in mean serum IGF-1 at an age equivalent to 40 weeks of gestation than at birth (25.21 ± 6.69 and 20.13 ± 5.46 p < 0.05). Multiple linear regression analysis showed that high birth weight, increased age of gestation and breastfeeding were correlated to the elevated serum level of IGF-1 at a postnatal age corresponding to 40 weeks gestational age.
Immediate breast milk feeding was accompanied by elevated IGF-1 in the serum of preterm infants.
胰岛素样生长因子1（IGF-1）是子宫内生长的重要激素介质之一，早产产后其血清值通常较低。
评估即刻母乳喂养对早产新生儿血清IGF-1的影响。
这项前瞻性观察队列研究纳入了60例孕周<32周的早产儿，根据母乳喂养或配方奶喂养分为A组和B组。出生时进行生长测量。计算每次测量的标准差。在出生后一天和相当于孕40周时测量血清IGF-I。
在相当于孕40周的校正年龄时，A组的平均血清IGF-1水平显著高于B组。在A组中，相当于孕40周时的平均血清IGF-1水平显著高于出生时（25.21±6.69和20.13±5.46，p<0.05）。多元线性回归分析表明，高出生体重、孕周增加和母乳喂养与相当于孕40周校正年龄时血清IGF-1水平升高相关。
即刻母乳喂养伴随早产儿血清IGF-1升高。
