Cardoso Rodrigo Kohn, Araujo Aline Machado, Orcy Rafael Bueno, Bohlke Maristela, Oses Jean Pierre, Del Vecchio Fabrício Boscolo, Barcellos Franklin Correa, Gonzalez Maria Cristina, Rombaldi Airton José
Post-Graduate Program of Physical Education, Federal University of Pelotas, Pelotas, RS, Brazil.
Department of Physiology and Pharmacology, Federal University of Pelotas, Pelotas, RS, Brazil.
MethodsX. 2019 Jan 23;6:190-198. doi: 10.1016/j.mex.2019.01.005. eCollection 2019.
Chronic kidney disease (CKD) is associated with physical weakness and increased oxidative stress and inflammation levels. Rehabilitation programs are associated with an improvement in the functional capacity, inflammatory and oxidative stress profile. Exercise associated with blood flow restriction (BFR) has been demonstrating positive effects in training programs, but there is lack information about exercise with BFR in CKD. Therefore, the aim of the present study is to describe a protocol using continuous moderate exercise with blood flow restriction (BFR) applied during hemodialysis (HD) to measures health indicators and immune system and oxidative stress parameters in CKD patients. Methods: A RTC will be conducted with 42 patients in HD. Baseline measures will be compared with final measures (anthropometric, cardiorespiratory, biochemical, muscle fitness, nutritional and behavioral questions). Participants will be randomly allocated to: 1) Continuous moderate exercise group with BFR; 2) Continuous moderate exercise group without BFR; 3) Control group without exercise. The intervention will be 12 weeks long during HD session. Patients will perform 20 min of continuous moderate exercise on a stationary bicycle three times a week. The present study is expected to generate significant information about the role of exercise with BFR in patients with CKD during HD.
慢性肾脏病（CKD）与身体虚弱以及氧化应激和炎症水平升高有关。康复计划与功能能力、炎症和氧化应激状况的改善相关。与血流限制（BFR）相结合的运动在训练计划中已显示出积极效果，但关于CKD患者进行BFR运动的信息匮乏。因此，本研究的目的是描述一种方案，即在血液透析（HD）期间应用连续中等强度运动结合血流限制（BFR）来测量CKD患者的健康指标、免疫系统和氧化应激参数。方法：将对42例HD患者进行随机对照试验（RTC）。将基线测量值与最终测量值（人体测量、心肺功能、生化指标、肌肉适应性、营养和行为问题）进行比较。参与者将被随机分配到：1）BFR连续中等强度运动组；2）无BFR连续中等强度运动组；3）无运动对照组。干预将在HD期间持续12周。患者将每周三次在固定自行车上进行20分钟的连续中等强度运动。本研究有望产生关于HD期间BFR运动在CKD患者中的作用的重要信息。
