Cytotoxic lycodine alkaloids from the aerial parts of .

A phytochemical investigation on the 75% EtOH extract of the aerial parts of resulted in the isolation of three new lycodine alkaloids, 16-hydroxy-9-oxo-lycocasuarinine D (), 6-hydroxy-16-dehydroxy-lycocasuarinine A (), and 6,16-dihydroxy-lycocasuarinine B (). Structural elucidation of all the compounds was performed by spectral methods such as 1D- and 2D-NMR, infrared, ultraviolet, and HR-ESI-MS. The isolated alkaloids were tested for cytotoxic potential against six lung cancer cell lines. Consequently, alkaloid exhibited cytotoxicity against all the tested tumor cell lines with IC values less than 20 μM.[Formula: see text].