Zhang Hai-Bo, Hu Jiang, Li Jia-Xun, Hao Shan-Hu
Department of Radiation Oncology, The General Hospital of Shenyang Military Area Command, Shenyang 110016, China.
College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
J Asian Nat Prod Res. 2020 Mar;22(3):217-224. doi: 10.1080/10286020.2018.1552681. Epub 2019 Feb 10.
A phytochemical investigation on the 75% EtOH extract of the aerial parts of resulted in the isolation of three new lycodine alkaloids, 16-hydroxy-9-oxo-lycocasuarinine D (), 6-hydroxy-16-dehydroxy-lycocasuarinine A (), and 6,16-dihydroxy-lycocasuarinine B (). Structural elucidation of all the compounds was performed by spectral methods such as 1D- and 2D-NMR, infrared, ultraviolet, and HR-ESI-MS. The isolated alkaloids were tested for cytotoxic potential against six lung cancer cell lines. Consequently, alkaloid exhibited cytotoxicity against all the tested tumor cell lines with IC values less than 20 μM.[Formula: see text].
对[植物名称]地上部分的75%乙醇提取物进行植物化学研究，从中分离出三种新的石蒜碱生物碱，16-羟基-9-氧代-石蒜碱D（）、6-羟基-16-去羟基-石蒜碱A（）和6,16-二羟基-石蒜碱B（）。通过一维和二维核磁共振、红外、紫外和高分辨电喷雾电离质谱等光谱方法对所有化合物进行结构解析。对分离得到的生物碱针对六种肺癌细胞系的细胞毒性潜力进行测试。结果，生物碱对所有测试的肿瘤细胞系均表现出细胞毒性，其半数抑制浓度（IC）值小于20 μM。[分子式：见正文]
