State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, China.
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Phytochemistry. 2018 Oct;154:63-72. doi: 10.1016/j.phytochem.2018.06.016. Epub 2018 Jul 5.
Thirteen previously undescribed lycodine-type Lycopodium alkaloids, namely, five alkaloids (lycocasuarines D-H) each possessing an uncommon five-membered C ring and eight Lycopodium alkaloid glycosides (casuarinosides A-H), together with a known analog, were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit (Lycopodiaceae). The structures of the compounds were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical methods. In addition, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.
从马尾杉（Lycopodiastrum casuarinoides（Spring）Holub ex R.D.Dixit）的地上部分分离得到 13 种以前未描述的石松堿型石松生物碱，分别为 5 种生物碱（lycocasuarines D-H），每种生物碱均具有不常见的五元 C 环和 8 种石松生物碱糖苷（casuarinosides A-H），以及一种已知类似物。通过广泛的光谱分析、单晶 X 射线衍射和化学方法阐明了这些化合物的结构。此外，还评估了分离得到的化合物对乙酰胆碱酯酶的抑制活性。
