石松属生物碱 Lycocasuarines I-Q，新分离自马尾杉 Lycopodiastrum casuarinoides。
Lycocasuarines I-Q, new Lycopodium alkaloids isolated from Lycopodiastrum casuarinoides.
机构信息
State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Engineering Laboratory of Chemical Resources Utilization in South Xinjiang of Xinjiang Production and Construction Corps, Tarim University, Alaer 843300, China.
出版信息
Fitoterapia. 2019 Apr;134:474-480. doi: 10.1016/j.fitote.2019.03.027. Epub 2019 Mar 25.
Lycocasuarines I-Q (1-9), nine new lycodine-type Lycopodium alkaloids were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit. Their structures were unambiguously determined via extensive spectroscopic analyses, including HRESIMS, NMR, and electronic circular dichroism (ECD). The new alkaloids were evaluated for their in vitro inhibitory activity against acetylcholinesterase (AChE). Compounds 3, 5-8 exhibited marginal or weak activities with IC values ranging from 97.2 to 171.9 μM.
石杉堿甲、乙、丙、丁、戊、己、庚、辛、壬（1-9），九个新的石杉堿型石杉生物碱从木贼科木贼属（Spring）Holub ex R.D.Dixit 的地上部分中分离得到。通过广泛的光谱分析，包括高分辨质谱、核磁共振和电子圆二色谱（ECD），明确确定了它们的结构。新的生物碱被评估了对体外乙酰胆碱酯酶（AChE）的抑制活性。化合物 3、5-8 表现出中等或弱的活性，IC 值范围为 97.2 至 171.9 μM。
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