组胺H受体拮抗剂可增强抗菌药物对大肠杆菌的疗效。
Histamine H receptor antagonists enhance the efficacy of antibacterials against Escherichia coli.
作者信息
Bruer G G, Hagedorn P, Kietzmann M, Tohamy A F, Filor V, Schultz E, Mielke-Kuschow S, Meissner J
机构信息
Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover Foundation, Hannover, Germany.
Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
出版信息
BMC Vet Res. 2019 Feb 11;15(1):55. doi: 10.1186/s12917-019-1797-9.
BACKGROUND
H receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to detect these possible effects in vitro. Studies were performed with two different Escherichia coli (E. coli) strains as test microbes, treated with antibacterials in combination with mepyramine.
RESULTS
The minimum inhibitory concentration (MIC) of E. coli ATCC® 25922™ and E. coli PIG 01 was reduced by combinations of the tested antibacterials with mepyramine.
CONCLUSIONS
These results have to be confirmed in vivo, before the use of antihistamines should be considered as potential way to minimize the amount of used antibacterials for treatment of E. coli infections.
背景
H 受体拮抗剂常用于治疗过敏性疾病。本研究的目的是确定像美吡拉敏这样的抗组胺化合物是否有能力影响抗菌药物的活性。因此，选择棋盘法在体外检测这些可能的作用。使用两种不同的大肠杆菌菌株作为测试微生物进行研究，将其用抗菌药物与美吡拉敏联合处理。
结果
测试的抗菌药物与美吡拉敏联合使用可降低大肠杆菌 ATCC® 25922™ 和大肠杆菌 PIG 01 的最低抑菌浓度（MIC）。
结论
在将使用抗组胺药视为减少治疗大肠杆菌感染所用抗菌药物量的潜在方法之前，这些结果必须在体内得到证实。
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