Hamed Ahmed Mohammed, Fatah Marwa Abdel, Shams Ghada Mohamed
All authors are with the Department of Dermatology and Andrology and Faculty of Medicine at Benha University, in Banha, Egypt.
J Clin Aesthet Dermatol. 2022 Jul;15(7):32-37.
The field of research into the probable link between androgenetic alopecia (AGA) and metabolic syndrome (MetS) is rapidly expanding. The exact underlying pathogenesis yet to be identified. Alarin, a galanin neuropeptide, found to be elevated in patients with metabolic syndrome and may represent a potential link between AGA and MetS.
The aim of this study was to assess serum levels of alarin in patients with AGA and investigate its possible correlation, if any, with criteria of MetS in those patients.
The study included 50 male patients with AGA and 30 healthy controls. Weight, height, waist circumference, and body mass index (BMI) were all measured. Systolic and diastolic blood pressure readings were recorded. Serum level of lipids, fasting blood glucose (FBG) and alarin were also assessed.
Anthropometric measures, serum lipids, FBG, and serum alarin were much higher in patients with AGA compared to controls (<0.05). Forty-one patients with AGA (82%) met the criteria for diagnosis of MetS. Serum level of alarin was significantly higher in those patients and correlated positively with severity and duration of AGA.
Serum level of alarin might represent a potential link between AGA and MetS, opening the door for better understanding of the pathogenesis of both conditions and the possible association between them.
雄激素性脱发（AGA）与代谢综合征（MetS）之间可能存在联系的研究领域正在迅速扩展。确切的潜在发病机制尚待确定。阿拉瑞林，一种甘丙肽神经肽，在代谢综合征患者中发现其水平升高，可能代表了AGA与MetS之间的潜在联系。
本研究的目的是评估AGA患者的血清阿拉瑞林水平，并调查其与这些患者的MetS标准之间可能存在的相关性（如果有的话）。
该研究纳入了50名男性AGA患者和30名健康对照者。测量了体重、身高、腰围和体重指数（BMI）。记录了收缩压和舒张压读数。还评估了血脂、空腹血糖（FBG）和阿拉瑞林的血清水平。
与对照组相比，AGA患者的人体测量指标、血脂、FBG和血清阿拉瑞林水平要高得多（<0.05）。41名AGA患者（82%）符合MetS的诊断标准。这些患者的血清阿拉瑞林水平显著更高，并与AGA的严重程度和病程呈正相关。
血清阿拉瑞林水平可能代表了AGA与MetS之间的潜在联系，为更好地理解这两种疾病的发病机制以及它们之间可能的关联打开了大门。
