Shams Ghada Mohamed, Saleh Ahmed Abdel-Wahab, Saeed Ahmed Mohamed, El-Damaty Safa Nabil, Abdel-Ghaffar Amira Osama
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.
Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.
Dermatol Pract Concept. 2023 Oct 1;13(4):e2023285. doi: 10.5826/dpc.1304a285.
Both Androgenetic alopecia (AGA) and age-related macular degeneration (AMD) shared the microinflammatory milieu and increased oxidative stress as important criteria in their pathogenesis. The monocyte/high density lipoprotein (HDL) ratio (MHR) seems to be an easy-to-calculate prognostic marker of microinflammation.
To assess MHR in patients with AGA and its correlation to AMD in these patients, if any.
Forty patients with AGA aged 40 years or more of both sexes and 40 control subjects participated in this case-control study. General, dermatological, and ophthalmologic examination, MHR evaluation and optical coherence tomography (OCT) were performed.
The mean MHR was significantly higher in AGA patients (6.98 ± 2.21) than in controls (3.82 ± 0.68) (P < 0.001). AMD was significantly higher in patients than controls (P < 0.001). Eighty percent of AGA patients were diagnosed with AMD versus 20% of control subjects. The presence of AMD in AGA was significantly related to the degree of severity of AGA in male patients (P = 0.02). The MHR was significantly higher in AGA patients found to have AMD (9.37 ± 1.1 and 7.01 ± 1.42 in the wet and dry type respectively) than those without AMD (P < 0.001).
AMD may develop more frequently in those with AGA. The MHR seems to be a missing link between both conditions, and could be utilized as a potential biomarker for predicting AMD in AGA patients.
雄激素性脱发（AGA）和年龄相关性黄斑变性（AMD）在发病机制上都有微炎症环境和氧化应激增加这两个重要特征。单核细胞/高密度脂蛋白（HDL）比值（MHR）似乎是一种易于计算的微炎症预后标志物。
评估AGA患者的MHR及其与这些患者中AMD的相关性（若存在）。
40名年龄在40岁及以上的AGA患者（男女均有）和40名对照受试者参与了这项病例对照研究。进行了全身、皮肤科和眼科检查、MHR评估以及光学相干断层扫描（OCT）。
AGA患者的平均MHR（6.98±2.21）显著高于对照组（3.82±0.68）（P<0.001）。患者中的AMD发生率显著高于对照组（P<0.001）。80%的AGA患者被诊断为AMD，而对照组为20%。AGA患者中AMD的存在与男性患者AGA的严重程度显著相关（P = 0.02）。被发现患有AMD的AGA患者的MHR（湿性和干性类型分别为9.37±1.1和7.01±1.42）显著高于未患AMD的患者（P<0.001）。
AMD在AGA患者中可能更频繁地发生。MHR似乎是这两种情况之间缺失的联系，可作为预测AGA患者发生AMD的潜在生物标志物。
