Qingdao University, Deng Zhou Road 38, Qingdao 266021, China.
Biochemistry Department No.2 Middle School Qingdao Shandong P.R. China 266000.
Int J Biol Sci. 2019 Jan 24;15(3):680-687. doi: 10.7150/ijbs.30464. eCollection 2019.
Reactive oxygen species (ROS) are a class of reactive molecules that have been implicated in a variety of cardiovascular diseases, accompanied by disorder of multiple signaling events. As cardiomyocytes maintain abundant of mitochondria, which supply the major source of endogenous ROS, oxidative damage to mitochondria often drives apoptotic cell death and initiates cardiac pathology. In recent years, non-coding RNAs (ncRNAs) have received much attention to uncover their roles in regulating gene expression during those pathological events in the heart, such as myocardial infarction, cardiac hypertrophy, and heart failure. Emerging evidences have highlighted that different ROS levels in response to diverse cardiac stresses result in differential expression of ncRNAs, subsequently altering the expression of pathogenetic genes. However, the knowledge about the ncRNA-linked ROS regulatory mechanisms in cardiac pathologies is still largely unexplored. In this review, we summarize the connections that exist among ROS, ncRNAs, and cardiac diseases to understand the interactions among the molecular entities underlying cardiac pathological events in the hopes of guiding novel therapies for heart diseases in the future.
活性氧（ROS）是一类具有反应活性的分子，它们与多种心血管疾病有关，并伴随着多种信号事件的紊乱。由于心肌细胞含有丰富的线粒体，而线粒体是内源性 ROS 的主要来源，因此线粒体的氧化损伤常常导致细胞凋亡和心脏病理的发生。近年来，非编码 RNA（ncRNA）受到了广泛关注，以揭示它们在心脏病理事件（如心肌梗死、心肌肥厚和心力衰竭）中调节基因表达的作用。越来越多的证据表明，不同的 ROS 水平对不同的心脏应激反应会导致 ncRNA 的差异表达，进而改变致病基因的表达。然而，关于 ncRNA 与 ROS 调节机制在心脏病理学中的联系，目前仍知之甚少。在这篇综述中，我们总结了 ROS、ncRNA 和心脏疾病之间的联系，以了解心脏病理事件中分子实体之间的相互作用，以期为未来的心脏病治疗提供新的思路。
