Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Oxid Med Cell Longev. 2021 Oct 23;2021:1208690. doi: 10.1155/2021/1208690. eCollection 2021.
In this review, we examine the multiple roles of ROS in the pathogenesis of melanoma, focusing on signal transduction and regulation of gene expression. In recent years, different studies have analyzed the dual role of ROS in regulating the redox system, with both negative and positive consequences on human health, depending on cell concentration of these agents. High ROS levels can result from an altered balance between oxidant generation and intracellular antioxidant activity and can produce harmful effects. In contrast, low amounts of ROS are considered beneficial, since they trigger signaling pathways involved in physiological activities and programmed cell death, with protective effects against melanoma. Here, we examine these beneficial roles, which could have interesting implications in melanoma treatment.
在这篇综述中，我们研究了 ROS 在黑色素瘤发病机制中的多种作用，重点关注信号转导和基因表达的调控。近年来，不同的研究分析了 ROS 在调节氧化还原系统中的双重作用，其对人类健康的影响既有负面的，也有正面的，这取决于这些物质在细胞内的浓度。ROS 水平的升高可能是由于氧化生成和细胞内抗氧化活性之间的平衡被打破所致，会产生有害影响。相比之下，少量的 ROS 被认为是有益的，因为它们可以触发参与生理活动和程序性细胞死亡的信号通路，对黑色素瘤具有保护作用。在这里，我们研究了这些有益的作用，这可能对黑色素瘤的治疗有重要意义。
