Van Tro Chau, Tat Thang Nguyen, Lan Anh Tran, Van Thuong Nguyen, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
Department of Dermatology, Pham Ngoc Thach University of Medicine, Vietnam.
Departments of Dermatology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
Open Access Maced J Med Sci. 2019 Jan 20;7(2):243-246. doi: 10.3889/oamjms.2019.061. eCollection 2019 Jan 30.
Atopic dermatitis (AD) is a common, chronic, relapsing, genetically determined inflammatory skin disorder. Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of AD. Atopic skin is susceptible to infection with .
This study was aimed to compare the skin colonisation status and its secretion of superantigens in adult AD and healthy subjects and to evaluate the efficacy of two treatment regimens (oral cefuroxime plus topical betamethasone dipropionate 0.05% versus topical betamethasone dipropionate 0.05%) in AD patients.
A group of 128 AD and 40 healthy subjects were recruited in this study and treatment efficacy was assessed by the SCORAD score.
was found in skin lesions in 83.8% of AD patients while only 37.5% of healthy subjects possessed this kind of bacteria in the external nares (p < 0.001). Superantigen production was more common in strains isolated from AD than the control group (58.6% versus 6.6%, p = 0.0006) and staphylococcal enterotoxin B was predominant (88.89%). 68 AD patients who had positive cultures with were included in a clinical therapeutic trial. The isolated bacteria were all sensitive to cefuroxime. Patients were randomised to receive either oral cefuroxime 500 mg b.i.d. Plus topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 1, 36 patients) or only topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 2, 32 patients). The mean SCORAD scores of group 1 at baseline and after 1 and 2 weeks of treatment were 44.61, 26.69 and 16.61, respectively. The corresponding values for group 2 were 43.03, 32.53 and 23.41, respectively.
The reduction in SCORAD scores was significantly higher in group 1 than group 2 in comparison to the baseline value of each study group (p = 0.003 after 1 week and p < 0.001 at the end of treatment).
特应性皮炎（AD）是一种常见的、慢性的、复发性的、由基因决定的炎症性皮肤病。金黄色葡萄球菌（金葡菌）在AD的发病机制中起重要作用。特应性皮肤易感染……
本研究旨在比较成年AD患者和健康受试者的皮肤定植状态及其超抗原分泌情况，并评估两种治疗方案（口服头孢呋辛加外用0.05%丙酸倍他米松与外用0.05%丙酸倍他米松）对AD患者的疗效。
本研究招募了128例AD患者和40名健康受试者，并通过SCORAD评分评估治疗效果。
83.8%的AD患者皮肤损伤处发现……，而只有37.5%的健康受试者在外鼻孔中有这种细菌（p<0.001）。从AD患者分离出的……菌株中超抗原产生比对照组更常见（58.6%对6.6%，p=0.0006），且葡萄球菌肠毒素B占主导（88.89%）。68例金葡菌培养阳性的AD患者被纳入临床治疗试验。分离出的细菌对头孢呋辛均敏感。患者被随机分为两组，一组口服头孢呋辛500mg，每日两次，加外用0.05%丙酸倍他米松，每日两次，共2周（即第1组，36例患者）；另一组仅外用0.05%丙酸倍他米松，每日两次，共2周（即第2组，32例患者）。第1组在基线时、治疗1周和2周后的平均SCORAD评分分别为44.61、26.69和16.61。第2组的相应值分别为43.03、32.53和23.41。
与各研究组的基线值相比，第1组的SCORAD评分降低幅度明显高于第2组（治疗1周后p=0.003，治疗结束时p<0.001）。
