10%氢氧化钾溶液与10%水杨酸软膏治疗传染性软疣的疗效——越南的低成本皮肤科疗法
Efficacy of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam.
作者信息
Huu Sau Nguyen, Quang Minh Nguyen, Van Thuong Nguyen, Cao Kiem Pham, Thu Hien Do Thi, Thi Lan Pham, Cam Van Tran, Huyen My Le, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
机构信息
National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Hanoi Medical University, Hanoi, Vietnam.
出版信息
Open Access Maced J Med Sci. 2019 Jan 28;7(2):269-271. doi: 10.3889/oamjms.2019.090. eCollection 2019 Jan 30.
BACKGROUND
Molluscum contagiosum is a common viral disease primarily affecting children.
AIM
The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum.
METHODS
Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug.
RESULTS
The clearance of all lesions after 2, 4, 6, 8 weeks of treatment in both groups were 7.7%; 23.1%; 53.8%; 79.5% and 0%; 3.2%, 9.7% 22.6%, respectively (p < 0.05). Side effects were seen in both groups include burning (76.9% versus 19.4%; p < 0.05); redness (59% versus 14%; p < 0.01); desquamation (12.8% versus 19.3%; p < 0.05).
CONCLUSION
The efficacy of KOH solution in the treatment of MC was better than that of salicylic pomade and both products are safe, effective, and easy to apply at home.
背景
传染性软疣是一种主要影响儿童的常见病毒性疾病。
目的
比较10%氢氧化钾（KOH）溶液与10%水杨酸软膏治疗传染性软疣的疗效。
方法
对70例患者进行临床试验，随机分为2组：39例患者接受10% KOH溶液治疗，31例患者接受10%水杨酸软膏治疗。评估基于病变的完全清除、药物的副作用和并发症。
结果
两组在治疗2、4、6、8周后所有病变的清除率分别为7.7%、23.1%、53.8%、79.5%和0%、3.2%、9.7%、22.6%（p<0.05）。两组均出现的副作用包括烧灼感（76.9%对19.4%；p<0.05）；发红（59%对14%；p<0.01）；脱屑（12.8%对19.3%；p<0.05）。
结论
KOH溶液治疗传染性软疣的疗效优于水杨酸软膏，两种产品均安全、有效且易于在家使用。
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