亚急性甲状腺炎患者甲状腺内甲状腺抗原反应性T淋巴细胞的积聚。
Accumulation of thyroid antigen-reactive T lymphocytes in the gland of patients with subacute thyroiditis.
作者信息
Tötterman T H, Gordin A, Häyry P, Andersson L C, Makinen T
出版信息
Clin Exp Immunol. 1978 Apr;32(1):153-8.
Blood and thyroid-infiltrating lymphocytes from patients with de Quervain's subacute thyroiditis were tested in the leucocyte migration inhibition test for cell-mediated immunity (CMI) to thyroid antigen. Blood leucocytes were positive for CMI in eleven out of thirteen (85%) patients in the acute phase of the disease. In five cases tested repeatedly this reactivity disappeared after 7-11 months. Thyroid-infiltrating lymphocytes were obtained from eight patients by fine-needle aspiration biopsy. There was a relative accumulation of T lymphocytes (90 +/- 5%) in the thyroid gland as compared to lower numbers of T cells (65 +/- 5%) in the blood. When thyroid-infiltrating lymphocytes were tested for CMI to thyroid antigen, a significantly stronger inhibition was demonstrated with the infiltrating lymphocytes as compared to that of blood leucocytes. We conclude that thyroid antigen-reactive T cells accumulate in the glands of patients with subacute thyroiditis. This observation is in accordance with the presumed viral aetiology of this disorder.
对亚急性甲状腺炎患者的血液及甲状腺浸润淋巴细胞进行白细胞游走抑制试验，以检测针对甲状腺抗原的细胞介导免疫（CMI）。在疾病急性期的13名患者中，有11名（85%）患者的血液白细胞CMI呈阳性。在5例反复检测的病例中，这种反应性在7 - 11个月后消失。通过细针穿刺活检从8名患者获取甲状腺浸润淋巴细胞。与血液中较少数量的T细胞（65±5%）相比，甲状腺中T淋巴细胞相对聚集（90±5%）。当检测甲状腺浸润淋巴细胞针对甲状腺抗原的CMI时，与血液白细胞相比，浸润淋巴细胞表现出显著更强的抑制作用。我们得出结论，亚急性甲状腺炎患者的腺体中会积累甲状腺抗原反应性T细胞。这一观察结果与该疾病推测的病毒病因相符。
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