青少年自身免疫性甲状腺炎中的血液及甲状腺浸润淋巴细胞亚群
Blood and thyroid-infiltrating lymphocyte subclasses in juvenile autoimmune thyroiditis.
作者信息
Tötterman T H, Mäenpää J, Gordin A, Mäkinen T, Taskinens E, Andersson L C, Häyry P
出版信息
Clin Exp Immunol. 1977 Nov;30(2):193-9.
We have studied the distribution of T and B lymphocytes in the blood and in the thyroid lymphocytic infiltrates (obtained by fine needle aspiration biopsy) in sixteen patients with juvenile autoimmune thyroiditis (JAIT). The same cell populations were also tested for cell-mediated immunity (CMI) to thyroid antigen in the leucocyte migration test (LMT). The relative and absolute numbers of blood T lymphocytes were normal (71-76%), as were the numbers of blood B lymphocytes (19%). The thyroid infiltrate contained 48% B lymphocytes, whereas only 40-44% of the infiltrating lymphocytes were T cells. Half of the JAIT patients showed a positive CMI to thyroid antigen with blood leucocytes, but when thyroid-infiltrating lymphocytes of these patients were tested in the LMT, they were negative. Thus, in contrast to what is generally assumed, we were unable to demonstrate T cell-dominated lymphocytic infiltrates or the accumulation of specifically sensitized T lymphocytes within the thyroid gland in autoimmune thyroiditis.
我们研究了16例青少年自身免疫性甲状腺炎（JAIT）患者血液及甲状腺淋巴细胞浸润灶（通过细针穿刺活检获取）中T淋巴细胞和B淋巴细胞的分布情况。同时，在白细胞迁移试验（LMT）中，对相同细胞群体针对甲状腺抗原的细胞介导免疫（CMI）进行了检测。血液中T淋巴细胞的相对及绝对数量正常（71%-76%），血液中B淋巴细胞数量也正常（19%）。甲状腺浸润灶中B淋巴细胞占48%，而浸润淋巴细胞中T细胞仅占40%-44%。一半的JAIT患者血液白细胞对甲状腺抗原的CMI呈阳性，但对这些患者的甲状腺浸润淋巴细胞进行LMT检测时，结果为阴性。因此，与通常的认识相反，我们未能在自身免疫性甲状腺炎患者的甲状腺内证实以T细胞为主的淋巴细胞浸润或特异性致敏T淋巴细胞的聚集。
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