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高脂饮食大鼠晶状体氧化损伤及硼水平的变化及淫羊藿提取物和白藜芦醇对其的影响。

Effects of L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet.

机构信息

Marmara University Faculty of Dentistry, Department of Basic Medical Sciences-Biochemistry, İstanbul, Turkey.

Ege University Faculty of Science, Department of Biochemistry, İzmir, Turkey.

出版信息

Turk J Ophthalmol. 2021 Dec 28;51(6):344-350. doi: 10.4274/tjo.galenos.2021.27981.

DOI:10.4274/tjo.galenos.2021.27981
PMID:34963261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8715658/
Abstract

OBJECTIVES

Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD).

MATERIALS AND METHODS

Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined.

RESULTS

The HFD increased serum triglyceride (p<0.05), total cholesterol level (p<0.001), body weight (p<0.001), and lens MDA levels (p<0.01) and decreased lens GSH (p<0.05) and boron level (p<0.01), SOD (p<0.001), and CAT activity (p<0.001). However, Myr and Apo treatment reduced the rats' body weight (p<0.001), serum triglyceride (p<0.05), and total cholesterol level (p<0.001) and increased lens boron (p<0.01; p<0.001), GSH levels (p<0.05; p<0.01), and CAT activity (p<0.001).

CONCLUSION

Both Myr and Apo may be able to reduce oxidative stress in the lenses of obese rats caused by HFD by increasing boron levels.

摘要

目的

营养性肥胖通过增加自由基的形成，导致体内氧化剂损伤和晶状体白内障形成。桃金娘叶提取物（Myr）具有抗氧化特性，而 apocynin（Apo）是一种有效的 NADPH-氧化酶抑制剂。关于组织硼水平的数据相当缺乏。本研究旨在探讨 Myr 和 Apo 治疗对高脂饮食（HFD）喂养大鼠硼水平和氧化晶状体损伤的影响。

材料和方法

将 Wistar 白化雄性大鼠随机分为四组：对照组、HFD 组、HFD+Myr 组和 HFD+Apo 组。实验前后测定体重和血脂。大鼠断头后取出晶状体并匀浆。测定晶状体匀浆中过氧化氢酶（CAT）和超氧化物歧化酶（SOD）的活性以及硼、丙二醛（MDA）和还原型谷胱甘肽（GSH）的水平。

结果

HFD 增加了血清甘油三酯（p<0.05）、总胆固醇水平（p<0.001）、体重（p<0.001）和晶状体 MDA 水平（p<0.01），降低了晶状体 GSH（p<0.05）和硼水平（p<0.01）、SOD（p<0.001）和 CAT 活性（p<0.001）。然而，Myr 和 Apo 治疗降低了大鼠体重（p<0.001）、血清甘油三酯（p<0.05）和总胆固醇水平（p<0.001），并增加了晶状体硼（p<0.01；p<0.001）、GSH 水平（p<0.05；p<0.01）和 CAT 活性（p<0.001）。

结论

Myr 和 Apo 均可通过增加硼水平，减少 HFD 引起的肥胖大鼠晶状体的氧化应激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/438c55c067c3/TJO-51-344-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/2cfce0b211a3/TJO-51-344-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/66ce39fc1491/TJO-51-344-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/e2c9fe31cda3/TJO-51-344-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/438c55c067c3/TJO-51-344-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/2cfce0b211a3/TJO-51-344-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/66ce39fc1491/TJO-51-344-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/e2c9fe31cda3/TJO-51-344-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ea/8715658/438c55c067c3/TJO-51-344-g4.jpg

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本文引用的文献

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