Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital (CWZ), Nijmegen, The Netherlands.
Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Mycoses. 2019 May;62(5):408-412. doi: 10.1111/myc.12903. Epub 2019 Mar 12.
Candida auris is a globally emerging yeast, causing severe infections in patients with underlying diseases. This yeast is responsible for several outbreaks within healthcare facilities, where it can be found on hospital surfaces and patient care devices. Spread from these fomites may be prevented by improving the decontamination of hospital surfaces. UV-C decontamination may constitute an effective adjunct to routine room cleaning.
Our aim was to investigate the effect of different UV-C exposure times and distance in killing C auris, using strains from different countries.
Candida auris was seeded on glass slides and exposed to UV-C for 5, 10, 20 and 30 minutes at 2 and 4 m.
A maximal effect of C auris killing was found after 30 minutes of UV-C exposure at 2 m. With half the time or twice the distance, the efficacy strongly diminished to ~10 and ~50 fold, respectively. At suboptimal exposure times and distances, the C auris strains from Japan/Korea were more sensitive to UV-C killing than C auris strains originating from Venezuela, Spain and India.
Altogether, UV-C exposure times and distance are the most critical parameters to kill C auris, while strain variations of C auris also determine UV-C efficacy. Future studies should aim to determine the effect and place of UV-C on surface decontamination in hospital setting.
耳念珠菌是一种在全球范围内新兴的酵母菌，可导致患有基础疾病的患者发生严重感染。这种酵母菌是医疗机构内数次爆发性感染的罪魁祸首，可在医院表面和患者护理设备上发现。通过改进医院表面的消毒，可以预防这些传播媒介的传播。UV-C 消毒可能是常规房间清洁的有效辅助手段。
我们旨在研究不同的 UV-C 暴露时间和距离对来自不同国家的菌株杀灭耳念珠菌的效果。
将耳念珠菌接种到载玻片上，并在 2 和 4 m 处分别暴露于 UV-C 下 5、10、20 和 30 分钟。
在 2 m 处进行 30 分钟的 UV-C 照射后，发现对耳念珠菌的杀灭效果达到最大值。暴露时间减半或距离增加一倍时，效果大大减弱至约 10 倍和 50 倍。在次优的暴露时间和距离下，来自日本/韩国的耳念珠菌菌株比来自委内瑞拉、西班牙和印度的耳念珠菌菌株对 UV-C 杀灭更为敏感。
总的来说，UV-C 暴露时间和距离是杀灭耳念珠菌的最关键参数，而耳念珠菌菌株的变异也决定了 UV-C 的功效。未来的研究应旨在确定 UV-C 在医院环境表面消毒中的效果和位置。
