Youinou P, Mackenzie L, le Masson G, Papadopoulos N M, Jouquan J, Pennec Y L, Angelidis P, Katsikis P, Moutsopoulos H M, Lydyard P M
Department of Immunology, Brest University Medical School, France.
J Autoimmun. 1988 Apr;1(2):185-94. doi: 10.1016/0896-8411(88)90025-x.
CD5, the human counterpart of Ly-1 molecules in the mouse, are detectable but weakly expressed on a minute fraction of circulating B cells. The number of CD5 + B cells in the blood of patients with Sjögren's syndrome was slightly higher than in control blood, but it became statistically significant after treatment of the cells with phorbol myristic acetate. These numbers were even higher in patients with homogeneous serum bands than in the others. A few scattered cells were stained with anti-human IgM antibody on salivary gland sections, and among them 5-10% were found to be positive for anti-CD5.
CD5是小鼠Ly-1分子在人类中的对应物，可在一小部分循环B细胞上检测到，但表达较弱。干燥综合征患者血液中CD5+B细胞的数量略高于对照血液，但在用佛波酯肉豆蔻酸酯处理细胞后，这一差异具有统计学意义。血清带均匀的患者中这些细胞数量比其他患者更高。在唾液腺切片上，少数散在细胞被抗人IgM抗体染色，其中5%-10%被发现抗CD5呈阳性。
