爱泼斯坦-巴尔病毒生命周期和发病机制中的细胞外囊泡
Extracellular Vesicles in Epstein-Barr Virus' Life Cycle and Pathogenesis.
作者信息
Zhao Mengmeng, Nanbo Asuka, Sun Lichun, Lin Zhen
机构信息
Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA 70112, USA.
Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
出版信息
Microorganisms. 2019 Feb 11;7(2):48. doi: 10.3390/microorganisms7020048.
Abstract
Extracellular vesicles (EVs), including exosomes and microvesicles, are evolutionarily conserved phospholidpid membrane-bound entities secreted from most eukaryotic cell types. They carry bioactive cargos such as protein and nucleic acids derived from their cells of origin. Over the past 10 years, they have been attracting increased attention in many fields of life science, representing a new route for intercellular communication. In this review article, we will discuss the current knowledge of both normal and virally modified EVs in the regulation of Epstein-Barr virus (EBV)'s life cycle and its associated pathogenesis.
摘要
细胞外囊泡（EVs），包括外泌体和微囊泡，是从大多数真核细胞类型分泌的具有进化保守性的磷脂膜结合实体。它们携带生物活性物质，如源自其起源细胞的蛋白质和核酸。在过去十年中，它们在生命科学的许多领域引起了越来越多的关注，代表了一种细胞间通讯的新途径。在这篇综述文章中，我们将讨论正常和病毒修饰的细胞外囊泡在调节爱泼斯坦-巴尔病毒（EBV）生命周期及其相关发病机制方面的现有知识。
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