Li Lu, Wu Jialin, Cai Jianghui, Asghar Muhammad Arif, Xiao Rui, Wu Jingwei, Zhao Qinjian, Zhang Xiao
College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China.
Infect Med (Beijing). 2025 Jun 22;4(3):100194. doi: 10.1016/j.imj.2025.100194. eCollection 2025 Sep.
Epstein-Barr Virus (EBV) is a widespread human γ-herpesvirus linked to cancers and autoimmune diseases, but limited comprehensive bibliometric analysis appear to have been conducted in this field.
Using Web of Science data, 16,318 EBV-related documents (2014-2023) were analyzed via VOSviewer, Bibliometrix, and Citespace following the Strengthening the Reporting of Observational Studies in Epidemiology reporting guideline.
This cross-sectional bibliometric analysis of 16,318 EBV-related documents (2014-2023) revealed a consistent upward trend in annual publications, reflecting growing global interest in EBV research. Collaborative networks demonstrated strong international partnerships, particularly between the United States and China. Keywords co-occurrence and burst analysis highlighted enduring focus on EBV pathogenesis, immune evasion mechanisms, and EBV-associated diseases like nasopharyngeal carcinoma, Hodgkin lymphoma, and multiple sclerosis. On the basis of this comprehensive bibliometric analysis, it showed that the emerging hotspots included immunotherapy, biomarkers, viral reactivation, and vaccine development, with clinical trials evaluating immune-checkpoint inhibitors of toripalimab, mRNA-based therapeutic vaccines targeting LMP2 and EBNA1, and prophylactic strategies such as glycoproteins-based ferritin nanoparticles or mRNA vaccines, indicating a shift toward precision interventions.
EBV research has grown exponentially, driven by insights into structural-function relationships and immune evasion. Advances enable targeted prophylactic/therapeutic strategies. The analysis highlights needs to decode virus-host interactions, optimize vaccines, and translate findings clinically, aiming to raise disease awareness, guide immunotherapies, and reduce global health burdens.
爱泼斯坦-巴尔病毒（EBV）是一种广泛传播的人类γ-疱疹病毒，与癌症和自身免疫性疾病有关，但该领域似乎进行的全面文献计量分析有限。
利用科学网数据，按照加强流行病学观察性研究报告指南，通过VOSviewer、Bibliometrix和Citespace对16318篇EBV相关文献（2014 - 2023年）进行分析。
对16318篇EBV相关文献（2014 - 2023年）的横断面文献计量分析显示，年度出版物呈持续上升趋势，反映出全球对EBV研究的兴趣日益增加。合作网络显示出强大的国际伙伴关系，尤其是美国和中国之间。关键词共现和爆发分析突出了对EBV发病机制、免疫逃逸机制以及EBV相关疾病如鼻咽癌、霍奇金淋巴瘤和多发性硬化症的持续关注。基于这一全面的文献计量分析，结果表明新兴热点包括免疫治疗、生物标志物、病毒再激活和疫苗开发，临床试验评估了托瑞帕利单抗的免疫检查点抑制剂、针对LMP2和EBNA1的基于mRNA的治疗性疫苗，以及基于糖蛋白的铁蛋白纳米颗粒或mRNA疫苗等预防策略，表明正在向精准干预转变。
EBV研究呈指数增长，这得益于对结构-功能关系和免疫逃逸的深入了解。这些进展使靶向预防/治疗策略成为可能。该分析强调需要解码病毒-宿主相互作用、优化疫苗并将研究结果转化为临床应用，旨在提高疾病认知、指导免疫治疗并减轻全球健康负担。
