Pereira João, Eugénio Gisela, Calretas Suzana, Santos Rui, Carvalho Armando
Department A of Internal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Eur J Case Rep Intern Med. 2016 Feb 23;3(3):000374. doi: 10.12890/2016_000374. eCollection 2016.
Malignant neoplasms are associated with a wide range of paraneoplastic rheumatological syndromes. These can be defined as remote effects of cancer, which are not caused by the tumor and its metastasis. The authors describe the case of an 82-year-old man, who presented with a one-month history of pain, stiffness, and functional limitation of the scapular and pelvic girdles. Blood tests showed raised levels of inflammatory markers. He was diagnosed with Polymyalgia Rheumatica, but the lack of response to corticosteroids led to the suspicion of an alternative diagnosis, like, for example, an occult neoplasm. Although patient evaluation was initially normal, five months later he developed macroscopic haematuria and was diagnosed with bladder and prostate carcinomas. After surgical treatment, the patient fully recovered from his rheumatological syndrome.
In cases when polymyalgia rheumatica exhibits atypical clinical features and/or therapeutic resistance, additional investigation is recommended.Paraneoplastic syndromes can lead to the diagnosis of an underlying neoplasm.
恶性肿瘤与多种副肿瘤性风湿综合征相关。这些综合征可定义为癌症的远隔效应,并非由肿瘤及其转移所致。作者描述了一名82岁男性的病例,该患者有肩胛骨和骨盆带疼痛、僵硬及功能受限1个月的病史。血液检查显示炎症标志物水平升高。他被诊断为风湿性多肌痛,但对皮质类固醇治疗无反应导致怀疑有其他诊断,例如隐匿性肿瘤。尽管最初对患者的评估正常,但5个月后他出现肉眼血尿,被诊断为膀胱癌和前列腺癌。手术治疗后,患者的风湿综合征完全康复。
当风湿性多肌痛表现出非典型临床特征和/或治疗抵抗时,建议进行进一步检查。副肿瘤综合征可导致潜在肿瘤的诊断。