Fong Chun Wa, Lio Lin Ian, Pon Monica, Mok Toi Meng, Hou Ng
Department of Plastic Surgery, Centro Hospitalar Conde São Januário, Macau SAR.
Department of Psychiatry, Centro Hospitalar Conde São Januário, Macau SAR.
Eur J Case Rep Intern Med. 2018 Sep 27;5(9):000881. doi: 10.12890/2018_000881. eCollection 2018.
Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory condition characterized by tumefactive lesions that can affect multiple organs. Serum IgG4 levels may be elevated. Early recognition is sometimes difficult but is important to avoid irreversible organ damage. We describe the case of a 28-year-old male patient who presented with a 2-year history of recurrent low-grade fever, night sweats and non-specific manifestations. We eventually diagnosed IgG4-related aortitis by PET-CT scan. The patient was successfully treated with prednisolone and mycophenolate mofetil with complete clinical and radiological resolution.
IgG4-related disease is a systemic immune-mediated disease that can affect many organs and systems.Aortitis can be one of the differential diagnoses in patients with fever of unknown origin, back pain and other unspecific symptoms.Delayed diagnosis and treatment may cause major complications or irreversible damage, so timely diagnosis and appropriate treatment is very important.
免疫球蛋白G4相关疾病（IgG4-RD）是一种全身性免疫介导的纤维炎症性疾病，其特征为可影响多个器官的肿块样病变。血清IgG4水平可能升高。早期识别有时很困难，但对于避免不可逆的器官损害很重要。我们描述了一名28岁男性患者的病例，该患者有2年反复低热、盗汗及非特异性表现的病史。我们最终通过PET-CT扫描诊断为IgG4相关主动脉炎。患者接受泼尼松龙和霉酚酸酯治疗成功，临床和影像学表现完全缓解。
IgG4相关疾病是一种可影响许多器官和系统的全身性免疫介导疾病。主动脉炎可能是不明原因发热、背痛及其他非特异性症状患者的鉴别诊断之一。诊断和治疗延迟可能导致严重并发症或不可逆损害，因此及时诊断和适当治疗非常重要。
