Ardila-Suarez Oscar, Abril Andy, Gómez-Puerta José A
Servicio de Medicina Interna, Hospital Manuel Uribe Angel, Envigado, Antioquia, Colombia.
Department of Rheumatology, Mayo Clinic, Jacksonville, Florida, Estados Unidos.
Reumatol Clin. 2017 May-Jun;13(3):160-166. doi: 10.1016/j.reuma.2016.05.009. Epub 2016 Jun 18.
IgG4-related disease is the term used to refer to a condition characterized by a lymphoplasmacytic infiltrate, fibrosis and an increased number of IgG4+ cells present in tissue, in most cases, with an elevated serum IgG4 level. This disease frequently affects the pancreas, salivary glands and lymph nodes, but can involve almost any tissue. Its etiology and the exact role of the different inflammatory cells in the damage to the target organ is still unclear. As yet, there is no international consensus about diagnostic criteria for the disease, but there are important advances in its treatment and in the quest to achieve remission. We include a review of the history, possible pathogenesis, clinical manifestations, diagnostic approach and available therapeutic approaches.
IgG4相关性疾病是指一种以淋巴浆细胞浸润、纤维化以及组织中IgG4+细胞数量增加为特征的病症，在大多数情况下，血清IgG4水平会升高。这种疾病常累及胰腺、唾液腺和淋巴结，但几乎可累及任何组织。其病因以及不同炎症细胞在靶器官损伤中的确切作用仍不清楚。目前，对于该疾病的诊断标准尚无国际共识，但在其治疗及实现缓解方面有了重要进展。我们纳入了对其历史、可能的发病机制、临床表现、诊断方法及现有治疗方法的综述。
