基于细胞的慢性阻塞性肺疾病治疗。重建肺部。
Cell-based Therapy for Chronic Obstructive Pulmonary Disease. Rebuilding the Lung.
机构信息
University of Vermont, Burlington, Vermont.
出版信息
Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S253-S259. doi: 10.1513/AnnalsATS.201808-534MG.
Abstract
As the prevalence and impact of lung diseases continue to increase worldwide, new therapeutic strategies are desperately needed. Advances in lung-regenerative medicine, a broad field encompassing stem cells, cell-based therapies, and a range of bioengineering approaches, offer new insights into and new techniques for studying lung physiology and pathophysiology. This provides a platform for the development of novel therapeutic approaches. Applicability to chronic obstructive pulmonary disease of recent advances and applications in cell-based therapies, predominantly those with mesenchymal stromal cell-based approaches, and bioengineering approaches for lung diseases are reviewed.
摘要
随着肺部疾病的患病率和影响在全球范围内不断增加，迫切需要新的治疗策略。肺再生医学领域的进展，涵盖了干细胞、基于细胞的疗法和一系列生物工程方法，为研究肺生理学和病理生理学提供了新的见解和技术。这为开发新的治疗方法提供了一个平台。本文综述了细胞疗法，尤其是基于间充质基质细胞的方法，以及用于肺部疾病的生物工程方法在慢性阻塞性肺疾病中的最新进展和应用。
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