Guenat Olivier T, Berthiaume François
Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, 08854, USA.
Biomicrofluidics. 2018 May 21;12(4):042207. doi: 10.1063/1.5024895. eCollection 2018 Jul.
In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and barriers of the human body. This article reviews those platforms, highlighting the different strains applied, and the actuation mechanisms and provides representative applications. A focus is placed on the skin and the lung barriers as examples, with a section that discusses the signaling pathways involved in the epithelium and the connective tissues.
在过去十年中，微纳加工和微流控技术的出现以及对细胞力学生物学兴趣的增加，引发了新型微流控平台的发展。这些平台旨在模拟作用于人体组织和屏障的机械应变环境。本文对这些平台进行了综述，重点介绍了所施加的不同应变、驱动机制，并提供了代表性应用。以皮肤和肺屏障为例进行重点介绍，其中有一部分讨论了上皮组织和结缔组织中涉及的信号通路。
