Justus Liebig University Giessen, Excellence Cluster Cardio-Pulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany; and member of the German Center for Lung Research (DZL), Germany.
Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S278-S281. doi: 10.1513/AnnalsATS.201808-532MG.
Chronic obstructive pulmonary disease (COPD) is one of the most important causes of death worldwide, and in addition to its impact on the patient's health, it poses a major socioeconomic burden. Tobacco smoke, indoor cooking, and air pollution are major triggers of the disease. This article summarizes evidence for the concept that lung microvascular molecular alterations can be a driver of lung emphysema. If findings from preclinical models allow a transfer to the human situation, this concept can offer new approaches for curative treatment of lung emphysema.
慢性阻塞性肺疾病（COPD）是全球最重要的死亡原因之一，除了对患者健康的影响外，还造成了重大的社会经济负担。烟草烟雾、室内烹饪和空气污染是该疾病的主要诱因。本文总结了肺微血管分子改变可能是肺肺气肿驱动因素的这一概念的证据。如果临床前模型的研究结果能够转化为人类情况，这一概念可以为肺肺气肿的治疗提供新的方法。
