Kim Dohyun, Yoo Jae Hyun, Park Young Woo, Kim Minchul, Shin Dong Woo, Jeong Bumseok
Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, South Korea.
School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
Front Hum Neurosci. 2019 Jan 29;13:12. doi: 10.3389/fnhum.2019.00012. eCollection 2019.
Despite the critical impact of parental dialog on children who remain physically and psychologically dependent, most studies have focused on brain alterations in people exposed to moderate-to-high levels of emotional maltreatment with/without psychopathology. We measured metabolites in the pregenual anterior cingulate cortex (pgACC) acquired with single-voxel proton magnetic resonance spectroscopy and anatomical connectivity assessed with probabilistic tractography in 46 healthy young adults who experienced no-to-low level parental verbal abuse (paVA) during their childhood and adolescence. The partial least square regression (PLSR) model showed that individual variance of perceived paVA was associated with chemical properties and structural connectivity of pregenual anterior cingulate cortex (pgACC; prediction = 0.23). The jackknife test was used to identify features that significantly contributed to the partial least square regression (PLSR) model; a negative association of paVA was found with myo-inositol concentration, anatomical connectivities with the right caudate and with the right transverse temporal gyrus. Of note, positive associations were also found with the left pars triangularis, left cuneus, right inferior temporal cortex, right entorhinal cortex and right amygdala. Our results showing both a negative association of frontal glial function and positive associations of anatomical connectivities in several networks associated with threat detection or visual information processing suggest both anatomical and neurochemical adaptive changes in medial frontolimbic networks to low-level paVA experiences.
尽管父母对话对仍存在身体和心理依赖的儿童有至关重要的影响，但大多数研究都集中在遭受中度至高度情感虐待且有/无精神病理学问题的人群的大脑改变上。我们对46名在童年和青少年时期未经历或经历过低水平父母言语虐待（paVA）的健康年轻人，用单体素质子磁共振波谱测量了前扣带回膝前部（pgACC）的代谢物，并用概率性纤维束成像评估了解剖连接性。偏最小二乘回归（PLSR）模型显示，感知到的paVA的个体差异与前扣带回膝前部（pgACC）的化学性质和结构连接性相关（预测值 = 0.23）。采用留一法检验来识别对偏最小二乘回归（PLSR）模型有显著贡献的特征；发现paVA与肌醇浓度、与右侧尾状核以及与右侧颞横回的解剖连接呈负相关。值得注意的是，还发现与左侧三角部、左侧楔叶、右侧颞下皮质、右侧内嗅皮质和右侧杏仁核呈正相关。我们的结果显示，额叶胶质功能呈负相关，而在与威胁检测或视觉信息处理相关的几个网络中解剖连接呈正相关，这表明内侧额边缘网络对低水平paVA经历存在解剖学和神经化学适应性变化。
