使用酵母双杂交试验对583种化学物质的内分泌干扰活性进行筛选数据。
Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay.
作者信息
Shiraishi Fujio, Kamata Ryo, Terasaki Masanori, Takigami Hidetaka, Imaizumi Yoshitaka, Yagishita Mayuko, Nakajima Daisuke
机构信息
National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
出版信息
Data Brief. 2018 Nov 23;21:2543-2546. doi: 10.1016/j.dib.2018.11.071. eCollection 2018 Dec.
We screened 583 chemicals for receptor binding activity to the human estrogen receptor (hER), the Japanese medaka estrogen receptor (medER), and the aryl hydrocarbon receptor (AhR) using the yeast two-hybrid assay. The substances tested included substances that could potentially be produced unintentionally by industrial processes, such as halogenated steroids and phenols. Antagonistic effects on hER and the androgen receptor were also screened. The test chemicals were selected for screening on the basis of chemical structure associated with possible estrogen receptor binding activity. The current study presents the report on the screening of 583 chemicals for different kinds of endocrine disrupting activity.
我们使用酵母双杂交试验，筛选了583种化学物质与人类雌激素受体（hER）、日本青鳉雌激素受体（medER）和芳烃受体（AhR）的受体结合活性。所测试的物质包括可能由工业过程无意产生的物质，如卤代类固醇和酚类。还筛选了对hER和雄激素受体的拮抗作用。根据与可能的雌激素受体结合活性相关的化学结构选择测试化学品。本研究报告了对583种化学物质进行不同类型内分泌干扰活性筛选的情况。
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