Laboratorio de Ecología Microbiana y Productos Naturales Marinos, Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México, Sisal, Yucatán, Mexico.
CICY - Centro de Investigación Científica de Yucatán, A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida, Yucatán, Mexico.
Microb Ecol. 2019 May;77(4):839-851. doi: 10.1007/s00248-019-01329-3. Epub 2019 Feb 14.
The quest for novel natural products has recently focused on the marine environment as a source for novel microorganisms. Although isolation of marine-derived actinomycete strains is now common, understanding their distribution in the oceans and their adaptation to this environment can be helpful in the selection of isolates for further novel secondary metabolite discovery. This study explores the taxonomic diversity of marine-derived actinomycetes from distinct environments in the coastal areas of the Yucatan Peninsula and their adaptation to the marine environment as a first step towards novel natural product discovery. The use of simple ecological principles, for example, phylogenetic relatedness to previously characterized actinomycetes or seawater requirements for growth, to recognize isolates with adaptations to the ocean in an effort to select for marine-derived actinomycete to be used for further chemical studies. Marine microbial environments are an important source of novel bioactive natural products and, together with methods such as genome mining for detection of strains with biotechnological potential, ecological strategies can bring useful insights in the selection and identification of marine-derived actinomycetes for novel natural product discovery.
最近，人们对新型天然产物的探索聚焦于海洋环境，将其作为新型微生物的来源。虽然从海洋中分离放线菌菌株现在已经很常见，但了解它们在海洋中的分布及其对这种环境的适应能力有助于选择用于进一步发现新型次生代谢产物的分离物。本研究探讨了尤卡坦半岛沿海地区不同环境中海洋来源放线菌的分类多样性及其对海洋环境的适应能力，这是发现新型天然产物的第一步。例如，使用简单的生态原则，如与先前表征的放线菌的系统发育相关性或生长对海水的需求，来识别对海洋有适应能力的分离物，从而选择用于进一步化学研究的海洋来源放线菌。海洋微生物环境是新型生物活性天然产物的重要来源，结合基因组挖掘等检测具有生物技术潜力的菌株的方法，生态策略可以为选择和鉴定用于新型天然产物发现的海洋来源放线菌提供有用的见解。
