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尤卡坦半岛察克伊察天然井中部分真菌的化学多样性研究

Insights into the Chemical Diversity of Selected Fungi from the Tza Itzá Cenote of the Yucatan Peninsula.

作者信息

Fajardo-Hernández Carlos A, Khan Firoz Shah Tuglak, Flores-Bocanegra Laura, Prieto-Davó Alejandra, Wan Baojie, Ma Rui, Qader Mallique, Villanueva-Silva Rodrigo, Martínez-Cárdenas Anahí, López-Lobato Marian A, Hematian Shabnam, Franzblau Scott G, Raja Huzefa A, García-Contreras Rodolfo, Figueroa Mario

机构信息

Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.

Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, North Carolina 27402, United States.

出版信息

ACS Omega. 2022 Mar 28;7(14):12171-12185. doi: 10.1021/acsomega.2c00544. eCollection 2022 Apr 12.

DOI:10.1021/acsomega.2c00544
PMID:35449929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9016812/
Abstract

Cenotes are habitats with unique physical, chemical, and biological features. Unexplored microorganisms from these sinkholes represent a potential source of bioactive molecules. Thus, a series of cultivable fungi ( spp. NCA257, NCA264, and NCA276, sp. NCA252, and sp. NCA273) isolated from the cenote Tza Itzá were subjected to chemical, coculture, and metabolomic analyses. Nineteen compounds were obtained and tested for their antimicrobial potential against ESKAPE pathogens, , and nontuberculous mycobacteria. In particular, phenylspirodrimanes from sp. NCA252 showed significant activity against MRSA, MSSA, and mycobacterial strains. On the other hand, the absolute configuration of the new compound 17-deoxy-aspergillin PZ () isolated from sp. NCA276 was established via single-crystal X-ray crystallography. Also, the chemical analysis of the cocultures between and strains revealed the production of metabolites that were not present or were barely detected in the monocultures. Finally, molecular networking analysis of the LC-MS-MS/MS data for each fungus was used as a tool for the annotation of additional compounds, increasing the chemical knowledge on the corresponding fungal strains. Overall, this is the first systematic chemical study on fungi isolated from a sinkhole in Mexico.

摘要

天然井是具有独特物理、化学和生物学特征的栖息地。来自这些污水坑的未被探索的微生物代表了生物活性分子的潜在来源。因此，对从Tza Itzá天然井分离出的一系列可培养真菌（NCA257、NCA264和NCA276种，NCA252种，以及NCA273种）进行了化学、共培养和代谢组学分析。获得了19种化合物，并测试了它们对ESKAPE病原体、[具体病原体名称缺失]和非结核分枝杆菌的抗菌潜力。特别是，来自NCA252种的苯基螺二氢茚对耐甲氧西林金黄色葡萄球菌、甲氧西林敏感金黄色葡萄球菌和分枝杆菌菌株表现出显著活性。另一方面，通过单晶X射线晶体学确定了从NCA276种分离出的新化合物17-脱氧曲霉毒素PZ（[具体结构或编号缺失]）的绝对构型。此外，[两种菌株名称缺失]菌株之间共培养的化学分析揭示了在单培养中不存在或几乎未检测到的代谢产物的产生。最后，对每种真菌的液相色谱-质谱-串联质谱数据进行分子网络分析，作为注释其他化合物的工具，增加了对相应真菌菌株的化学知识。总体而言，这是对从墨西哥一个污水坑分离出的真菌进行的首次系统化学研究。

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