College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, P. R. China.
CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105, Funchal, Portugal.
Chem Biodivers. 2020 Dec;17(12):e2000562. doi: 10.1002/cbdv.202000562. Epub 2020 Nov 18.
Marine organism-associated actinobacteria represent a valuable resource for marine drugs due to their abundant secondary metabolites. The special environments in the ocean, for instance, high salt, high pressure, low temperature and oligotrophy, not only adapt to survival of actinomycetes but also enhance molecular diversity of actinomycete secondary metabolites production, thus making marine actinomycetes important sources of marine-based bioactive compounds, especially polyketides. Herein, we summarized the structures and pharmacological activities of polyketides from actinobacteria associated with marine organisms from 2013 to 2019; moreover, the main source species of actinomycetes were discussed as well. We expected that this review would be helpful for future in-depth research and development of marine-based bioactive polyketides.
海洋生物相关放线菌由于其丰富的次生代谢产物，是海洋药物的宝贵资源。海洋中的特殊环境，如高盐、高压、低温和贫营养，不仅适应放线菌的生存，而且增强了放线菌次生代谢产物产生的分子多样性，因此海洋放线菌是海洋生物活性化合物的重要来源，尤其是聚酮类化合物。本文综述了 2013 年至 2019 年海洋生物相关放线菌来源的聚酮类化合物的结构和药理活性，并讨论了主要的放线菌来源种。我们希望这篇综述有助于对海洋生物活性聚酮类化合物的进一步深入研究和开发。
