Faculdade Vale do Salgado FVS, Departamento de Enfermagem, Icó, CE, Brasil.
Universidade Regional do Cariri - URCA, Departamento de Química Biológica, Crato, CE, Brasil.
Nat Prod Res. 2020 Aug;34(16):2384-2388. doi: 10.1080/14786419.2018.1537273. Epub 2019 Feb 14.
The present study aimed to evaluate the antibacterial and modulatory activity of the methyl extract in isolation or in combination with aminoglycoside antibiotics, using the microdilution method. The methyl extract was used in isolation in the antibacterial assays and in combination with antibiotics in the modulation assays. All tests were performed in triplicates. The methyl extract presented both antibacterial and antibiotic-modulatory effects in isolation and in association with aminoglycosides. The extract activity depends on the bacterial strain and may be associated with the presence of tannins and flavonols. However, further studies are required to characterize the potential for the development of new drugs against multiresistant bacteria.
本研究旨在评估甲基提取物的抗菌和调节活性，使用微量稀释法进行分离或与氨基糖苷类抗生素联合使用。在抗菌测定中，甲基提取物单独使用，在调节测定中与抗生素联合使用。所有测试均重复进行三次。甲基提取物在分离和与氨基糖苷类药物联合使用时均具有抗菌和抗生素调节作用。提取物的活性取决于细菌菌株，可能与单宁和类黄酮的存在有关。然而，需要进一步的研究来表征开发针对多药耐药菌的新药的潜力。
