Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand.
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand.
Am J Trop Med Hyg. 2019 Apr;100(4):783-790. doi: 10.4269/ajtmh.18-0761.
Dengue virus (DENV) causes asymptomatic to severe life-threatening infections and affects millions of people worldwide. Autophagy, a cellular degradative pathway, has both proviral and antiviral functions. Dengue virus triggers the autophagy pathway for the successful replication of its genome. However, the exact mechanism and the viral factors involved in activating this pathway remain unclear. This review summarizes the existing knowledge on the mechanism of autophagy induction and its significance during DENV infection.
登革热病毒（DENV）可引起无症状到危及生命的严重感染，影响全球数百万人。自噬是一种细胞降解途径，具有促病毒和抗病毒功能。登革热病毒触发自噬途径以成功复制其基因组。然而，激活该途径的确切机制和病毒因子仍不清楚。本综述总结了自噬诱导的机制及其在 DENV 感染过程中的意义的现有知识。
