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Therapeutic exploitation of the S-nitrosoglutathione/S-nitrosylation mechanism for the treatment of contusion spinal cord injury.

作者信息

Khan Mushfiquddin, Singh Inderjit

机构信息

Department of Pediatrics, Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA.

出版信息

Neural Regen Res. 2019 Jun;14(6):973-974. doi: 10.4103/1673-5374.250572.

DOI:10.4103/1673-5374.250572
PMID:30762004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6404493/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba8/6404493/7ef88a2da254/NRR-14-973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba8/6404493/79313411ff12/NRR-14-973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba8/6404493/7ef88a2da254/NRR-14-973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba8/6404493/79313411ff12/NRR-14-973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba8/6404493/7ef88a2da254/NRR-14-973-g002.jpg

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本文引用的文献

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BMC Neurosci. 2018 Aug 13;19(1):50. doi: 10.1186/s12868-018-0450-z.
2
Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI.在创伤性脑损伤小鼠模型中，靶向神经元型一氧化氮合酶/过氧亚硝酸盐/钙蛋白酶系统以赋予神经保护作用并促进功能恢复。
Brain Res. 2016 Jan 1;1630:159-70. doi: 10.1016/j.brainres.2015.11.015. Epub 2015 Nov 17.
3
Promoting endothelial function by S-nitrosoglutathione through the HIF-1α/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats.
Neural Regen Res. 2021 Sep;16(9):1793-1794. doi: 10.4103/1673-5374.306080.
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Ormosanine improves neuronal functions in spinal cord-injured rats by blocking peroxynitrite/calpain activity.麦仙翁碱通过阻断过氧亚硝酸盐/钙蛋白酶活性改善脊髓损伤大鼠的神经元功能。
Transl Neurosci. 2020 May 29;11(1):182-191. doi: 10.1515/tnsci-2020-0106. eCollection 2020.
通过HIF-1α/VEGF途径，S-亚硝基谷胱甘肽促进内皮功能，刺激大鼠实验性中风后的神经修复和功能恢复。
Drug Des Devel Ther. 2015 Apr 17;9:2233-47. doi: 10.2147/DDDT.S77115. eCollection 2015.
4
Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury.将神经保护、再生和修复机制转化应用于脊髓损伤的治疗
Prog Brain Res. 2015;218:15-54. doi: 10.1016/bs.pbr.2014.12.007. Epub 2015 Mar 29.
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