工厂和建筑工作与 MRI 检查中严重腰椎椎管狭窄的风险增加有关：和歌山脊柱研究中的病例对照分析。
Factory and construction work is associated with an increased risk of severe lumbar spinal stenosis on MRI: A case control analysis within the wakayama spine study.
机构信息
MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, Hampshire, United Kingdom.
Orthopedic surgery, Wakayama Medical University, Wakayama city, Wakayama prefecture, Japan.
出版信息
Am J Ind Med. 2019 May;62(5):430-438. doi: 10.1002/ajim.22957. Epub 2019 Feb 14.
BACKGROUND
To explore the association of MRI-diagnosed severe lumbar spinal stenosis with occupation.
METHODS
Occupational data were collected by questionnaire and all participants underwent spine MRI scans using the same protocol. Central lumbar spinal stenosis (LSS) was graded qualitatively. Those with severe LSS (>two-thirds narrowing) were compared with the controls with lesser degrees of stenosis or no stenosis.
RESULTS
Data were available for 722 subjects, mean age 70.1 years. 239 (33%) cases with severe LSS were identified. Factory/construction workers had an almost four-fold increased risk of severe LSS after adjustment for age, sex, smoking, and walking speed amongst those aged <75 years (OR 3.97, 95%CI 1.46-10.85). Severe LSS was also associated with squatting ≥1 h/day (OR 1.76, 95%CI 1.01-3.07) but this association became non-significant after adjustment.
CONCLUSION
Further research is needed but this study adds more evidence that occupational factors are associated with an increased risk and/or severity of degenerative disease of the lumbar spine.
背景
探讨 MRI 诊断的严重腰椎椎管狭窄与职业之间的关系。
方法
通过问卷调查收集职业数据，所有参与者均采用相同方案进行脊柱 MRI 扫描。对中央腰椎椎管狭窄（LSS）进行定性分级。将严重 LSS（>三分之二狭窄）患者与狭窄程度较轻或无狭窄的对照组进行比较。
结果
共纳入 722 名受试者，平均年龄 70.1 岁。共发现 239 例（33%）严重 LSS 患者。对于年龄<75 岁的人群，与工厂/建筑工人相比，重度 LSS 的风险几乎增加了四倍（OR 3.97，95%CI 1.46-10.85），在调整年龄、性别、吸烟和行走速度等因素后。重度 LSS 还与每天蹲坐≥1 小时有关（OR 1.76，95%CI 1.01-3.07），但调整后该关联不再显著。
结论
需要进一步研究，但本研究进一步证明了职业因素与腰椎退行性疾病的风险增加和/或严重程度有关。
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