Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Department of Infectious Diseases, Hospital Beatriz Ângelo, Loures, Portugal.
PLoS One. 2019 Feb 14;14(2):e0212283. doi: 10.1371/journal.pone.0212283. eCollection 2019.
To investigate the association between current CD4+ T-cell count and CD4/CD8+ ratio with severity of frailty among people aging with HIV.
Cross-sectional observational study analysing data from all study visits in the ongoing prospective Modena HIV Metabolic Clinic Cohort between 2006 and 2015. Frailty severity was assessed using a frailty index (FI). We visualized the relationships between frailty index score and current CD4 cell count and CD4/CD8 ratio on two different curves adjusted for age, sex, and duration of HIV infection.
Frailty index scores exhibited an inverse relationship with current CD4 count, up to 900 cells/μL. The CD4/CD8 ratio was inversely correlated with frailty index both below and above the cut-off of 900 CD4 cells/μL.
Frailty in PLWH is inversely associated with both immune-activation, depicted by CD4/CD8 ratio and immune-deficit depicted by CD4 count. The first association shows a linear shape while the second shows a hook-shape with a turning point at 900 cells. Above this cut off level CD4 do not represent a significant risk factor for frailty.
研究 HIV 感染者的 CD4+T 细胞计数和 CD4/CD8+比值与虚弱严重程度之间的关联。
这是一项横断面观察性研究，分析了 2006 年至 2015 年期间正在进行的前瞻性莫德纳 HIV 代谢临床队列的所有研究访问中的数据。使用虚弱指数（FI）评估虚弱严重程度。我们在两条不同的曲线上可视化了 FI 评分与当前 CD4 细胞计数和 CD4/CD8 比值之间的关系，这些曲线分别调整了年龄、性别和 HIV 感染持续时间。
FI 评分与当前 CD4 计数呈负相关，直至 900 个细胞/μL。CD4/CD8 比值与 FI 均呈负相关，低于和高于 900 个 CD4 细胞/μL 的截断值。
PLWH 的虚弱与免疫激活（由 CD4/CD8 比值表示）和免疫缺陷（由 CD4 计数表示）均呈负相关。第一个关联呈线性，第二个关联呈钩形，在 900 个细胞处有一个转折点。在此截断值以上，CD4 不再是虚弱的显著危险因素。
