Brañas Fátima, Sánchez-Conde Matilde, Carli Federica, Menozzi Marianna, Raimondi Alessandro, Milic Jovana, Franconi Jacopo, Cuomo Gianluca, Mussini Cristina, Moreno Santiago, Guaraldi Giovanni
Geriatrics Department, Hospital Universitario Infanta Leonor, Universidad Complutense, Madrid, Spain.
Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain; and.
J Acquir Immune Defic Syndr. 2020 Mar 1;83(3):284-291. doi: 10.1097/QAI.0000000000002259.
To evaluate differences between older women and men with HIV regarding HIV variables, comorbidity, physical function, and quality of life (QOL).
The Modena HIV clinic.
Prospective cohort study. Cross-sectional analysis. Patients >50 years were included, stratified by sex. We recorded sociodemographic data, comorbidities, variables related to HIV infection, frailty, data on body composition, physical function, physical activity, and QOL.
We evaluated 1126 older adults with HIV, of which 284 (25.2%) were women. Median age was 55 (IQR 6) years. There were significant differences between women and men in the median current CD4 T-cell and the mean CD4/CD8 ratio. There were differences regarding alcohol consumption, cardiovascular (CV) disease, hypertension, diabetes mellitus, and renal failure. Sarcopenia and slower gait speed were found more prevalent among men, but without significant differences. Significant differences were found regarding lower extremity strength measured by the chair stand test and in the short physical performance battery score. Short physical performance battery <9 was detected for 11.1% women vs. 5.6% men (P = 0.002). EQ5D5L score was 0.87 in women vs. 0.89 in men (P = 0.002).
In our cohort, older women represented one in 4 of the total patients. Despite the fact that women have better immunological recovery measured by CD4 T-cell count and CD4/CD8 ratio, and fewer CV disease and CV risk factors than men, their physical function and their QOL are worse. Therefore, older HIV-infected women have special characteristics, and the assessment of physical function in this group seems to be crucial.
评估感染艾滋病毒的老年女性和男性在艾滋病毒相关变量、合并症、身体功能和生活质量（QOL）方面的差异。
摩德纳艾滋病毒诊所。
前瞻性队列研究。横断面分析。纳入年龄>50岁的患者，并按性别分层。我们记录了社会人口学数据、合并症、与艾滋病毒感染相关的变量、虚弱状况、身体成分数据、身体功能、身体活动和生活质量。
我们评估了1126名感染艾滋病毒的老年人，其中284名（25.2%）为女性。中位年龄为55岁（四分位间距6岁）。女性和男性在当前CD4 T细胞中位数和平均CD4/CD8比值方面存在显著差异。在饮酒、心血管（CV）疾病、高血压、糖尿病和肾衰竭方面存在差异。肌肉减少症和步态速度较慢在男性中更为普遍，但无显著差异。通过椅子站立试验测量的下肢力量和简短体能测试得分存在显著差异。简短体能测试<9分的女性占11.1%，男性占5.6%（P = 0.002）。女性的EQ5D5L评分为0.87，男性为0.89（P = 0.002）。
在我们的队列中，老年女性占总患者的四分之一。尽管通过CD4 T细胞计数和CD4/CD8比值测量，女性的免疫恢复情况优于男性，且患心血管疾病和心血管危险因素的人数少于男性，但其身体功能和生活质量更差。因此，感染艾滋病毒的老年女性具有特殊特征，对该群体身体功能的评估似乎至关重要。
