Reproductive Medicine Center, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
Int J Gynaecol Obstet. 2019 May;145(2):212-218. doi: 10.1002/ijgo.12787. Epub 2019 Mar 13.
To assess three-dimensional (3D) ultrasound combined with power Doppler (PD) for the differential diagnosis of endometrial lesions among infertile women.
A prospective study carried out at a reproductive medicine center in Luoyang, China, between January and December 2015. The inclusion criteria were asymptomatic infertility with normal endometrium or specific endometrial lesions. Participants were subdivided by whether they had normal endometrium (group 1, n=357), or endometrial lesions including polyps, hyperplasia, intrauterine adhesions, or endometritis (group 2, n=99). 3D PD and hysteroscopy were performed in the follicular phase. Endometrial thickness, volume, vascularization index (VI), flow index (FI), and vascularization flow index (VFI), and subendometrial VI, FI, and VFI were calculated. Endometrial lesions were confirmed by pathologic analysis.
The overall prevalence of endometrial lesions was 99/456 (21.3%). Endometrial thickness and volume were significantly larger in group 2 than in group 1 (9.96 ± 3.24 vs 8.15 ± 2.50 mm and 3.70 ± 2.54 vs 2.42 ± 1.64 cm , respectively; both P<0.001). Endometrial thickness and volume were larger among women with endometrial polyps and hyperplasia; endometrial VI, FI, and VFI were lower among women with intrauterine adhesions.
Three-dimensional PD has value for the differential diagnosis of endometrial lesions among infertile women.
The trial is registered in the Chinese Clinical Trial Registry as ChiCTR1800015799.
评估三维（3D）超声联合能量多普勒（PD）对不孕妇女子宫内膜病变的鉴别诊断。
这是一项在中国洛阳生殖医学中心进行的前瞻性研究，时间为 2015 年 1 月至 12 月。纳入标准为无症状性不孕且子宫内膜正常或有特定子宫内膜病变。根据是否存在正常子宫内膜（第 1 组，n=357）或包括息肉、增生、宫腔粘连或子宫内膜炎在内的子宫内膜病变（第 2 组，n=99）将参与者进行分组。所有参与者均在卵泡期进行 3D PD 和宫腔镜检查。计算子宫内膜厚度、体积、血管化指数（VI）、血流指数（FI）和血管化血流指数（VFI），以及子宫下段 VI、FI 和 VFI。通过病理分析确定子宫内膜病变。
子宫内膜病变的总患病率为 99/456（21.3%）。第 2 组的子宫内膜厚度和体积明显大于第 1 组（9.96±3.24 比 8.15±2.50 mm 和 3.70±2.54 比 2.42±1.64 cm ，均 P<0.001）。子宫内膜息肉和增生患者的子宫内膜厚度和体积较大；宫腔粘连患者的子宫内膜 VI、FI 和 VFI 较低。
3D PD 对不孕妇女的子宫内膜病变具有鉴别诊断价值。
本试验在中国临床试验注册中心注册，注册号为 ChiCTR1800015799。
Zotero 插件