Tan Shu-Yin, Hang Fu, Purvarshi Gowreesunkur, Li Min-Qing, Meng Da-Hua, Huang Ling-Ling
Department of Obstetrics and Gynecology, GuangXi Women and Children Hospital, GuangXi, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of GuangXi Medical University, GuangXi, China.
Taiwan J Obstet Gynecol. 2015 Oct;54(5):522-6. doi: 10.1016/j.tjog.2014.10.008.
To evaluate the predictive value of three-dimensional (3D)-power Doppler sonography on recurrent miscarriage.
The study patients were divided into a recurrent miscarriage group (30 cases) and a normal pregnancy group (21 cases). Measurement of endometrial thickness was performed using two-dimensional transvaginal ultrasound in the midluteal phase. The endometrial volume, vascularization index (VI), flow index (FI), and vascularization-flow index (VFI) in midluteal and placenta volume, as well as the VI, FI, and VFI of early pregnancy were measured using Virtual Organ Computer-aided Analysis of 3D-power Doppler ultrasound.
Endometrial thickness, endometrial volume, endometrial vascular data, VI, FI, and VFI of the midluteal phase were lower in the recurrent miscarriage group compared with the normal pregnancy group (p < 0.05). Placental volume, VI, and VFI during early pregnancy were lower in the miscarriage group compared with the normal pregnancy group (p < 0.05). There was no significant change in FI between the recurrent miscarriage and control groups during early pregnancy (p > 0.05). The predictive accuracy of endometrial thickness, endometrial volume, VI, FI, and VFI in the midluteal phase, and placenta volume, VI, FI, and VFI in early pregnancy as measured by the receiver operating characteristic curve to predict miscarriage before 12 gestational weeks in participants was 0.681, 0.876, 0.770, 0.720, 0.879, 0.771, 0.907, 0.592, respectively.
The 3D-power Doppler ultrasound is a more comprehensive and sensitive method for evaluating endometrial receptivity. Endometrial volume, VI, FI, and VFI in the midluteal phase, as well as VI in early pregnancy, can be considered as predictive factors for recurrent miscarriage.
评估三维（3D）-能量多普勒超声对复发性流产的预测价值。
将研究对象分为复发性流产组（30例）和正常妊娠组（21例）。在黄体中期采用二维经阴道超声测量子宫内膜厚度。使用3D-能量多普勒超声的虚拟器官计算机辅助分析测量黄体中期的子宫内膜体积、血管化指数（VI）、血流指数（FI）和血管化血流指数（VFI），以及胎盘体积，同时测量早期妊娠的VI、FI和VFI。
与正常妊娠组相比，复发性流产组黄体中期的子宫内膜厚度、子宫内膜体积、子宫内膜血管数据、VI、FI和VFI均较低（p < 0.05）。与正常妊娠组相比，流产组早期妊娠的胎盘体积、VI和VFI较低（p < 0.05）。复发性流产组与对照组在早期妊娠期间FI无显著变化（p > 0.05）。通过受试者工作特征曲线测量，黄体中期的子宫内膜厚度、子宫内膜体积、VI、FI和VFI，以及早期妊娠的胎盘体积、VI、FI和VFI预测参与者妊娠12周前流产的准确性分别为0.681、0.876、0.770、0.720、0.879、0.771、0.907、0.592。
3D-能量多普勒超声是评估子宫内膜容受性更全面、更敏感的方法。黄体中期的子宫内膜体积、VI、FI和VFI，以及早期妊娠的VI可被视为复发性流产的预测因素。
