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用于可见检测和准确识别MPEA蒸汽的比率荧光探针。

Ratiometric fluorescence probes for visible detection and accurate identification of MPEA vapor.

作者信息

Miao Xin, Wu Chunxiao, Xia Yuanxing, Yu Shilong, Li Feng, Zhang Ming

机构信息

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.

Department of Fundamental Study of Public Security, Criminal Investigation Police University of China, Shenyang, 110854, P. R. China.

出版信息

Nat Commun. 2024 Dec 6;15(1):10641. doi: 10.1038/s41467-024-55011-5.

DOI:10.1038/s41467-024-55011-5
PMID:39643618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11624257/
Abstract

Methamphetamine (MA), as one kind of overflowed synthetic illicit drugs, has posed severe threats to health and social security. However, the on-site and visible fluorescence detection to MA remains limited. Herein, through covalently coupling diphenylacridine (DPA) and dimethylacridine (DMA) with pyridine, two ratiometric fluorescence probes (PyDPA and PyDMA) are constructed, which present rapid response, bathochromic-shifts over 100 nm and visible fluorescence color changes from blue to cyan upon the exposure to methylphenethylamine (MPEA, a simulant of MA). And the similar responses are observed for MA in confiscated samples. Further, a smartphone-based quantitative detected system is established to provide the on-site trace detection of MPEA as ppb level. Specially, PyDPA or PyDMA can identify MPEA from its interferences according to the unique ratiometric response based on their dual-emission-enhancement. Here, we show two ratiometric fluorescence probes to MA and MPEA with high potential for on-site application.

摘要

甲基苯丙胺（MA）作为一种泛滥的合成非法药物，对健康和社会安全构成了严重威胁。然而，对MA的现场可见荧光检测仍然有限。在此，通过将二苯基吖啶（DPA）和二甲基吖啶（DMA）与吡啶共价偶联，构建了两种比率荧光探针（PyDPA和PyDMA），它们对甲基苯乙胺（MPEA，MA的模拟物）具有快速响应、超过100 nm的红移以及从蓝色到青色的可见荧光颜色变化。在没收样品中对MA也观察到类似的响应。此外，建立了基于智能手机的定量检测系统，以实现对MPEA的现场痕量检测，检测限为ppb水平。特别地，PyDPA或PyDMA可以根据其基于双发射增强的独特比率响应，从干扰物中识别出MPEA。在此，我们展示了两种对MA和MPEA具有高现场应用潜力的比率荧光探针。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/651653e317e0/41467_2024_55011_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/d88dd9480613/41467_2024_55011_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/5f6b6a07d9ce/41467_2024_55011_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/79ca7b47e6f9/41467_2024_55011_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/1512e8f2b4ce/41467_2024_55011_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/d1cb36e7509f/41467_2024_55011_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/e254a613b12e/41467_2024_55011_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/27985ba1a195/41467_2024_55011_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/5d28505200cf/41467_2024_55011_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/651653e317e0/41467_2024_55011_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/d88dd9480613/41467_2024_55011_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/5f6b6a07d9ce/41467_2024_55011_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/79ca7b47e6f9/41467_2024_55011_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/1512e8f2b4ce/41467_2024_55011_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/d1cb36e7509f/41467_2024_55011_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/e254a613b12e/41467_2024_55011_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/27985ba1a195/41467_2024_55011_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/5d28505200cf/41467_2024_55011_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/11624257/651653e317e0/41467_2024_55011_Fig9_HTML.jpg

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本文引用的文献

[1]
A simple AIE probe to pesticide trifluralin residues in aqueous phase: Ultra-fast response, high sensitivity, and quantitative detection utilizing a portable platform.

Talanta. 2024-3-1

[2]
Combining presumptive color tests, pressure-sensitive adhesive-based collection, and paper spray-mass spectrometry for illicit drug detection.

Analyst. 2023-7-10

[3]
Functionalisation of Graphene Sensor Surfaces for the Specific Detection of Biomarkers.

Angew Chem Int Ed Engl. 2023-5-22

[4]
Film-based fluorescent sensors: from sensing materials to hardware structures.

Sci Bull (Beijing). 2023-3-30

[5]
Direct Active Site at the Van der Waals Heterostructure Interface with Synthetic Drug Analogue -Methylphenethylimine Ultrasensitivity.

ACS Sens. 2023-3-24

[6]
Investigating the electrochemical profile of methamphetamine to enable fast on-site detection in forensic analysis.

Talanta. 2023-4-1

[7]
Turn-off near-infrared fluorescent probe for free bilirubin detection constructed by enhanced excimer emission.

Anal Chim Acta. 2023-1-15

[8]
Ultra-Sensitive, Selective and Repeatable Fluorescence Sensor for Methanol Based on a Highly Emissive 0D Hybrid Lead-Free Perovskite.

Angew Chem Int Ed Engl. 2022-8-26

[9]
Local detection of pH-induced disaggregation of biocompatible micelles by fluorescence switch ON.

Chem Sci. 2022-3-10

[10]
Nonlinear plexcitons: excitons coupled with plasmons in two-photon absorption.

Nanoscale. 2022-5-19

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