Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Cell Host Microbe. 2019 Feb 13;25(2):175-176. doi: 10.1016/j.chom.2019.01.012.
Intestinal cues driving prophage induction in the microbiota are largely unknown. In this issue of Cell Host & Microbe, Oh et al. (2018) reveal that dietary fructose- and microbiota-derived short-chain fatty acids promote AckA-mediated acetic acid biosynthesis, triggering a stress response that facilities phage production.
肠道线索在很大程度上驱动了微生物群中的噬菌体诱导，但目前尚不清楚这些肠道线索是什么。在本期《细胞宿主与微生物》中，Oh 等人揭示了饮食中的果糖和微生物衍生的短链脂肪酸促进 AckA 介导的乙酸生物合成，触发了有利于噬菌体产生的应激反应。
