Stanford University, Stanford, CA, USA.
University of Montana, Missoula, MT, USA.
Cell Host Microbe. 2019 Feb 13;25(2):177-179. doi: 10.1016/j.chom.2019.01.020.
Perturbation of the gut microbiota is associated with inflammatory bowel disease, obesity, and even cancer. In this issue of Cell Host & Microbe, Gogokhia et al. 2019 sought to kill cancer-causing bacteria with bacteriophages. However, the bacteriophages themselves directly stimulated an immune response, which worsened inflammatory bowel disease pathogenesis.
肠道微生物群的紊乱与炎症性肠病、肥胖症甚至癌症有关。在本期《Cell Host & Microbe》杂志上，Gogokhia 等人 2019 年试图用噬菌体杀死致癌细菌。然而，噬菌体本身直接刺激了免疫反应，从而加重了炎症性肠病的发病机制。
