病毒组多样性与成人同卵双胞胎肠道微生物组多样性相关。
Virome Diversity Correlates with Intestinal Microbiome Diversity in Adult Monozygotic Twins.
机构信息
Department of Microbiome Science, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
出版信息
Cell Host Microbe. 2019 Feb 13;25(2):261-272.e5. doi: 10.1016/j.chom.2019.01.019.
The virome is one of the most variable components of the human gut microbiome. Within twin pairs, viromes have been shown to be similar for infants, but not for adults, indicating that as twins age and their environments and microbiomes diverge, so do their viromes. The degree to which the microbiome drives the vast virome diversity is unclear. Here, we examine the relationship between microbiome and virome diversity in 21 adult monozygotic twin pairs selected for high or low microbiome concordance. Viromes derived from virus-like particles are unique to each individual, are dominated by Caudovirales and Microviridae, and exhibit a small core that includes crAssphage. Microbiome-discordant twins display more dissimilar viromes compared to microbiome-concordant twins, and the richer the microbiomes, the richer the viromes. These patterns are driven by bacteriophages, not eukaryotic viruses. Collectively, these observations support a strong role of the microbiome in patterning for the virome.
病毒组是人类肠道微生物组中最具变异性的组成部分之一。在双胞胎中，婴儿的病毒组相似，但成人的病毒组却不相似，这表明随着双胞胎年龄的增长，他们的环境和微生物组发生了分歧，病毒组也随之发生了变化。微生物组对巨大的病毒组多样性的影响程度尚不清楚。在这里，我们研究了 21 对选择高或低微生物组一致性的成年同卵双胞胎的微生物组和病毒组多样性之间的关系。源自病毒样颗粒的病毒组是每个人独有的，主要由长尾噬菌体目和微病毒科组成，并且具有包括 crAssphage 在内的小核心。与微生物组一致的双胞胎相比，微生物组不一致的双胞胎的病毒组差异更大，而微生物组越丰富，病毒组就越丰富。这些模式是由噬菌体驱动的，而不是真核病毒。总的来说，这些观察结果支持了微生物组在病毒组模式形成中起着重要作用。
Zotero 插件