The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Institute of Geriatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; The First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi, China.
Guangdong Provincial Institute of Geriatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; Wuhan No. 1 Hospital, Wuhan, Hubei, China.
Microbes Infect. 2019 Aug-Sep;21(7):296-304. doi: 10.1016/j.micinf.2019.01.005. Epub 2019 Feb 11.
Esophageal carcinoma, with a increasing incidence, is one of the most aggressive carcinomas in gastrointestinal tract. Epidemiologic studies demonstrate an association of oral pathogens with multiple diseases, including rheumatoid arthritis, cardiovascular diseases, diabetes, and gastrointestinal malignancies. Nevertheless, a causal relationship between oral pathogens and esophageal squamous cell carcinoma (ESCC) has not been elucidated. Here, we found that Porphyromonas was significantly enriched in the saliva of patients with ESCC, compared with that in normal human. In vitro studies showed that Porphyromonas gingivalis (P. gingivalis) promoted the proliferation and motility of ESCC cells, as evidenced by up regulated expression of key molecules implicated in NF-κB signaling pathway. These findings, for the first time, demonstrated a role of oral pathogens in inducing ESCC tumorigenesis and metastasis, which might involve regulation of NF-κB signaling pathway.
食管癌的发病率不断上升，是胃肠道中侵袭性最强的癌种之一。流行病学研究表明，口腔病原体与多种疾病相关，包括类风湿性关节炎、心血管疾病、糖尿病和胃肠道恶性肿瘤。然而，口腔病原体与食管鳞状细胞癌（ESCC）之间的因果关系尚未阐明。在这里，我们发现与正常人相比，ESCC 患者的唾液中明显富集了卟啉单胞菌。体外研究表明，牙龈卟啉单胞菌（P. gingivalis）促进 ESCC 细胞的增殖和运动，这表现为 NF-κB 信号通路中涉及的关键分子的表达上调。这些发现首次证明了口腔病原体在诱导 ESCC 肿瘤发生和转移中的作用，这可能涉及 NF-κB 信号通路的调节。
