Cancer Discov. 2019 Apr;9(4):458. doi: 10.1158/2159-8290.CD-NB2019-019. Epub 2019 Feb 14.
In mice predisposed to lung cancer, dysregulation of the lung's bacteria creates a proinflammatory environment that promotes tumor growth. Treating the animals with antibiotics or keeping them in bacteria-free conditions results in fewer and smaller tumors, implicating the local microbiota in the development of lung cancer.
在易患肺癌的老鼠中,肺部细菌的失调会产生促炎环境,从而促进肿瘤生长。用抗生素治疗动物或使它们处于无菌环境中会导致肿瘤数量减少和体积缩小,这表明局部微生物群与肺癌的发展有关。