Jin Xin, Gu Yangang, Song Xiaojie
Department of Clinical Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Department of Respiratory and Critical Care Medicine, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Front Microbiol. 2025 Mar 10;16:1558379. doi: 10.3389/fmicb.2025.1558379. eCollection 2025.
Microecology refers to the ecosystem formed by human and microbial communities in the process of co-evolution, the microecological imbalance is associated with occurrence and development of multiple diseases, including lung cancer. In this review, we detailedly summarized the concept and roles of microecology, the relationship between microecology and human diseases, and related techniques in microecology studies. Importantly, we specially analyzed the correlations between microecology and lung cancer by focusing on gut microbiota, oral microbiota and lower respiratory tract microbiota, and further evaluated the effects of microbiota dysbiosis on chemotherapy and immunotherapy efficacy in lung cancer. At last, we discussed the potential mechanisms by which dysregulated microbiota promotes the genesis and development of lung cancer. Microecology-centered detection and intervention will improve the early diagnosis of lung cancer and provide new targets for the treatment of lung cancer.
微生态学是指人类与微生物群落共同进化过程中形成的生态系统，微生态失衡与包括肺癌在内的多种疾病的发生发展相关。在本综述中，我们详细总结了微生态学的概念和作用、微生态学与人类疾病的关系以及微生态学研究中的相关技术。重要的是，我们通过聚焦肠道微生物群、口腔微生物群和下呼吸道微生物群，特别分析了微生态学与肺癌之间的相关性，并进一步评估了微生物群失调对肺癌化疗和免疫治疗疗效的影响。最后，我们讨论了微生物群失调促进肺癌发生发展的潜在机制。以微生态学为中心的检测和干预将改善肺癌的早期诊断，并为肺癌治疗提供新的靶点。
