Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway.
Neurogastroenterol Motil. 2019 May;31(5):e13559. doi: 10.1111/nmo.13559. Epub 2019 Feb 14.
Gastroenteritis has been associated with complications such as irritable bowel syndrome (IBS) and chronic fatigue (CF). Little is known about the implications for quality of life (QoL) in this setting. The aims of this study were to evaluate the association between exposure to Giardia infection and QoL ten years after the infection, and how this related to IBS and CF.
We followed 1252 patients with laboratory-verified Giardia lamblia infection and a matched control group for 10 years after an epidemic in Bergen, Norway, in 2004. The main outcome was QoL after ten years as defined by the Short-form 12 version 2 with a physical component summary (PCS) and a mental component summary (MCS), both with range 0-100 (T-score). Regression analyses were performed using mixed modeling.
Mean PCS T-score in the exposed group (51.4; 95% CI: 50.6-52.1) was 2.8 T-score points (95% CI: -3.8 to -1.9, P < 0.001) lower than that in the control group (54.2; 95% CI: 53.7-54.8). The mean MCS T-score was also 2.8 T-score points (95% CI: -3.8 to -1.9, P < 0.001) lower among the exposed (48.9; 95% CI: 48.2-49.6) than the controls (51.7; 95% CI: 51.1-52.4). Further analyses found that the effect of Giardia exposure on QoL was mediated by IBS and CF.
CONCLUSIONS & INFERENCES: Exposure to Giardia infection was associated with a lower QoL ten years later as compared to a control group, an effect that was mediated by IBS and CF.
肠胃炎与肠易激综合征（IBS）和慢性疲劳（CF）等并发症有关。然而，目前对于这种情况下的生活质量（QoL）的影响知之甚少。本研究旨在评估在感染后 10 年内暴露于贾第虫感染与 QoL 之间的关联，以及这种关联与 IBS 和 CF 的关系。
我们对 2004 年挪威卑尔根爆发的实验室确诊的蓝氏贾第鞭毛虫感染的 1252 名患者和匹配的对照组进行了 10 年的随访。主要结局是通过简短形式 12 版本 2 定义的 10 年后的 QoL，包括身体成分摘要（PCS）和心理成分摘要（MCS），两者的范围均为 0-100（T 评分）。使用混合模型进行回归分析。
暴露组的平均 PCS T 评分（51.4；95%置信区间：50.6-52.1）比对照组（54.2；95%置信区间：53.7-54.8）低 2.8 T 评分点（95%置信区间：-3.8 至-1.9，P < 0.001）。暴露组的平均 MCS T 评分也低 2.8 T 评分点（95%置信区间：-3.8 至-1.9，P < 0.001）（48.9；95%置信区间：48.2-49.6）比对照组（51.7；95%置信区间：51.1-52.4）。进一步的分析发现，贾第虫暴露对 QoL 的影响是由 IBS 和 CF 介导的。
与对照组相比，感染贾第虫后 10 年内的 QoL 较低，这种影响是由 IBS 和 CF 介导的。
