Key Laboratory of Symbol Computation & Knowledge Engineering of Ministry of Education, College of Computer Science & Technology, Jilin University, Changchun 130012, PR China.
Cancer Systems Biology Center, China-Japan Union Hospital, Jilin University, Changchun 130033, PR China.
Biomark Med. 2019 Feb;13(2):105-121. doi: 10.2217/bmm-2018-0273. Epub 2019 Feb 15.
Pancreatic cancer is one of the worst malignant tumors in prognosis. Therefore, to reduce the mortality rate of pancreatic cancer, early diagnosis and prompt treatment are particularly important.
We put forward a new feature-selection method that was used to find clinical markers for pancreatic cancer by combination of Support Vector Machine Recursive Feature Elimination (SVM-RFE) and Large Margin Distribution Machine Recursive Feature Elimination (LDM-RFE) algorithms. As a result, seven differentially expressed genes were predicted as specific biomarkers for pancreatic cancer because of their highest accuracy of classification on cancer and normal samples.
Three (MMP7, FOS and A2M) out of the seven predicted gene markers were found to encode proteins secreted into urine, providing potential diagnostic evidences for pancreatic cancer.
胰腺癌是预后最差的恶性肿瘤之一。因此,降低胰腺癌的死亡率,早期诊断和及时治疗尤为重要。
我们提出了一种新的特征选择方法,该方法结合支持向量机递归特征消除(SVM-RFE)和大间隔分布机递归特征消除(LDM-RFE)算法,用于寻找胰腺癌的临床标志物。结果,预测了七个差异表达基因作为胰腺癌的特异性生物标志物,因为它们对癌症和正常样本的分类准确性最高。
在预测的七个基因标志物中,有三个(MMP7、FOS 和 A2M)被发现编码分泌到尿液中的蛋白质,为胰腺癌提供了潜在的诊断依据。